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Substituted phenylmorpholines, or substituted phenmetrazines alternatively, are 
chemical derivative
In chemistry, a derivative is a compound that is derived from a similar compound by a chemical reaction.
In the past, derivative also meant a compound that ''can be imagined to'' arise from another compound, if one atom or group of atoms is repl ...
s of phenylmorpholine or of the psychostimulant drug phenmetrazine
Phenmetrazine ( INN, USAN, BAN) (brand name Preludin, and many others) is a stimulant drug first synthesized in 1952 and originally used as an appetite suppressant, but withdrawn from the market in the 1980s due to widespread abuse. It was initi ...
. Most such compounds act as releasers of monoamine neurotransmitters, and have stimulant effects. Some also act as agonists at serotonin receptors, and compounds with an N-propyl substitution act as dopamine receptor agonist
A dopamine agonist (DA) is a compound that activates dopamine receptors. There are two families of dopamine receptors, D2-like and D1-like, and they are all G protein-coupled receptors. D1- and D5-receptors belong to the D1-like family and the ...
s. A number of derivatives from this class have been investigated for medical applications, such as for use as anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By contrast, an appetite stimulant is referred to as orexigenic.
The term is (from the Greek ''ἀν-'' (an-) = "without" a ...
s or medications for the treatment of ADHD. Some compounds have also become subject to illicit use as designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...
s.
See also
* Substituted amphetamine * Substituted benzofuran * Substituted cathinone *Substituted methylenedioxyphenethylamine
Substitution reaction, Substituted methylenedioxy- phenethylamines (MDxx) are a large chemical class of derivative (chemistry), derivatives of the phenethylamines, which includes many psychoactive drugs that act as entactogens, psychedelic drug, ...
* List of aminorex analogues
This is a list of aminorex analogues. Aminorex itself is a stimulant drug with a 5-phenyl-2-amino-oxazoline structure. It was developed in the 1960s as an anorectic, but withdrawn from sale after it was discovered that extended use produced pulmon ...
* List of methylphenidate analogues
* List of phenyltropanes
* List of cocaine analogues
This is a list of cocaine analogues. A cocaine analogue is an (usually) artificial construct of a novel chemical compound from (often the starting point of natural) cocaine's molecular structure, with the result product sufficiently similar to co ...
References
External links
* {{Phenethylamines Anorectics Euphoriants Norepinephrine-dopamine releasing agents Chemical classes of psychoactive drugs