Phenylbiguanide (PBG) is a
5-HT3 agonist used to study the role of 5-HT3 receptors in the
central nervous system
The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...
. It has been found to trigger
dopamine release in the
nucleus accumbens
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the ''nucleus accumbens septi'', Latin for " nucleus adjacent to the septum") is a region in the basal forebrain rostral to the preoptic area of the hypot ...
of rats.
Derivatives
*Phenylbiguanide is used to make
amanozine and
benfosformin.
References
5-HT3 agonists
Biguanides
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