Peter Verveer Tishler, M.D. (July 18, 1937 – January 18, 2021) is a researcher in human

genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...

and

orphan diseases A rare disease is any disease that affects a small percentage of the population. In some parts of the world, an orphan disease is a rare disease whose rarity means there is a lack of a market large enough to gain support and resources for discove ...

, educator, and clinician especially in the areas of genetic diseases, including

polycystic kidney disease Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney. These cy ...

chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by long-term respiratory symptoms and airflow limitation. The main symptoms include shortness of breath and a cough, which may or may not produce ...

Fabry disease Fabry disease, also known as Anderson–Fabry disease, is a rare genetic disease that can affect many parts of the body, including the kidneys, heart, and skin. Fabry disease is one of a group of conditions known as lysosomal storage diseases. T ...

, and the

porphyria Porphyria is a group of liver disorders in which substances called porphyrins build up in the body, negatively affecting the skin or nervous system. The types that affect the nervous system are also known as acute porphyria, as symptoms are ra ...

Biography

Tishler was born on July 18, 1937 in Boston, Massachusetts to

Max Tishler Max Tishler (October 30, 1906 – March 18, 1989) was president of Merck Sharp and Dohme Research Laboratories where he led the research teams that synthesized ascorbic acid, riboflavin, cortisone, pyridoxine, pantothenic acid, nicotinamide, me ...

and Elizabeth M. Verveer, and grew up in

New Jersey New Jersey is a state in the Mid-Atlantic and Northeastern regions of the United States. It is bordered on the north and east by the state of New York; on the east, southeast, and south by the Atlantic Ocean; on the west by the Delaware ...

. He passed away January 18, 2021 in

Watertown, New York Watertown is a city in, and the county seat of, Jefferson County, New York, United States. It is approximately south of the Thousand Islands, along the Black River about east of where it flows into Lake Ontario. The city is bordered by the ...

. Tishler attended public schools and

Harvard College Harvard College is the undergraduate college of Harvard University, an Ivy League research university in Cambridge, Massachusetts. Founded in 1636, Harvard College is the original school of Harvard University, the oldest institution of higher lea ...

where he majored in

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

. He wrote his senior thesis on

carboxypeptidase A carboxypeptidase ( EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at ...

, in the lab of Dr. C.J. Fu at the

Jimmy Fund The Jimmy Fund, established in Boston in 1948, is made up of community-based fundraising events and other programs that benefit Dana-Farber Cancer Institute. Since 1948, millions of people have given money to the Jimmy Fund to help save lives an ...

, graduating ''

cum laude Latin honors are a system of Latin phrases used in some colleges and universities to indicate the level of distinction with which an academic degree has been earned. The system is primarily used in the United States. It is also used in some Sou ...

'' in 1959. Tishler attended

Yale School of Medicine The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary te ...

and graduated in 1962. While at Yale, Tishler began working with the Thorndike Memorial Laboratory at

Boston City Hospital The Boston City Hospital (1864–1996), in Boston, Massachusetts, was a public hospital, located in the South End. It was "intended for the use and comfort of poor patients, to whom medical care will be provided at the expense of the city, and . ...

from 1963 to 1977.

William B. Castle William Bainbridge Castle (November 30, 1814 – February 28, 1872) was an American politician of the Whig Party who served as the 11th and final mayor of Ohio City from 1853 to 1854 and the 14th mayor of Cleveland, Ohio from 1855 to 1856. Ca ...

, discoverer of

intrinsic factor Intrinsic factor (IF), cobalamin binding intrinsic factor, also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption o ...

, introduced him to Sidney H. Ingbar with whom Tishler began work on the metabolic actions of

thyroid hormone File:Thyroid_system.svg, upright=1.5, The thyroid system of the thyroid hormones T3 and T4 rect 376 268 820 433 Thyroid-stimulating hormone rect 411 200 849 266 Thyrotropin-releasing hormone rect 297 168 502 200 Hypothalamus rect 66 216 386 25 ...

Maxwell Finland Maxwell Finland (March 15, 1902 — October 25, 1987) was an American scientist, medical researcher, an expert on infectious diseases.] Finland led seminal research of antibiotic treatment of pneumonia. Early life and education Finland was born ...

contributed to Tishler’s scientific and clinical work.Finland, Maxwell and Castle, William B., Eds. (1983) ''The Harvard Medical Unit at Boston City Hospital, Volume II''. University of Virginia Press (for the Francis A. Countway Library of Medicine). Tishler’s interest in genetics arose from his laboratory research in the study of thyroid function in patients with

phenylketonuria Phenylketonuria (PKU) is an inborn error of metabolism that results in decreased metabolism of the amino acid phenylalanine. Untreated PKU can lead to intellectual disability, seizures, behavioral problems, and mental disorders. It may also resu ...

. During the

Vietnam War The Vietnam War (also known by #Names, other names) was a conflict in Vietnam, Laos, and Cambodia from 1 November 1955 to the fall of Saigon on 30 April 1975. It was the second of the Indochina Wars and was officially fought between North Vie ...

, Tishler worked as a

Public Health Service In public relations and communication science, publics are groups of individual people, and the public (a.k.a. the general public) is the totality of such groupings. This is a different concept to the sociological concept of the ''Öffentlichkei ...

officer at the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

. In the following years, he continued his basic laboratory work, but also was concerned with genetics and medicine in the terms of population and

epidemiology Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidenc ...

. He was also involved in familial studies of

hypertension Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. High blood pressure usually does not cause symptoms. Long-term high bl ...

at one of the first community health centers in the U.S., East Boston Neighborhood Health Center.

Selected publications

* * * * * * * * * * * *

References

External links

Peter Verveer Tishler
at

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...

Peter Verveer Tishler
at the American Porphyria Foundation {{DEFAULTSORT:Tishler, Peter 1937 births American epidemiologists American geneticists Medical educators Harvard University alumni American medical historians 2021 deaths 21st-century American historians 21st-century American male writers American male non-fiction writers