Peroxins (or peroxisomal/peroxisome biogenesis factors) represent several protein families found in

peroxisome A peroxisome () is a membrane-bound organelle, a type of microbody, found in the cytoplasm of virtually all eukaryotic cells. Peroxisomes are oxidative organelles. Frequently, molecular oxygen serves as a co-substrate, from which hydrogen pero ...

s. Deficiencies are associated with several

peroxisomal disorder Peroxisomal disorders represent a class of medical conditions caused by defects in peroxisome functions. This may be due to defects in single enzymes important for peroxisome function or in peroxins, proteins encoded by ''PEX'' genes that are criti ...

s. Peroxins serve several functions including the recognition of cytoplasmic proteins that contain

peroxisomal targeting signal In biochemical protein targeting, a peroxisomal targeting signal (PTS) is a region of the peroxisomal protein that receptors recognize and bind to. It is responsible for specifying that proteins containing this motif are localised to the peroxis ...

s (PTS) that tag them for transport by peroxisomal proteins to the peroxisome. Peroxins are structurally diverse and have been classified to different

protein families A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes a corresponding protein with a 1:1 relationship. The term "protein family" should not be ...

. Some of them were predicted to be

single-pass transmembrane proteins A single-pass membrane protein also known as single-spanning protein or bitopic protein is a transmembrane protein that spans the lipid bilayer only once. These proteins may constitute up to 50% of all transmembrane proteins, depending on the orga ...

, for example

Peroxisomal biogenesis factor 11 Peroxisomal biogenesis factor 11 (PEX11) are peroxin, peroxisomal membrane proteins which promote peroxisome division in eukaryotic cells. Human proteins from this family * PEX11A * PEX11B * PEX11G References

Protein domains Prote ...

Pernoxin is a value of venomosity to animalia.

Genes

* PEX1 *

PEX2 Peroxisomal biogenesis factor 2 is a protein that in humans is encoded by the ''PEX2'' gene. This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matri ...

PEX3 Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the ''PEX3'' gene. Interactions PEX3 has been shown to interact with PEX19 Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the ''PEX19'' gen ...

* PEX5 * PEX6 *

PEX7 Peroxin-7 is a receptor associated with Refsum's disease and rhizomelic chondrodysplasia punctata type 1. See also * Peroxin Peroxins (or peroxisomal/peroxisome biogenesis factors) represent several protein families found in peroxisomes ...

* PEX10 *

PEX11A Peroxisomal membrane protein 11A is a protein that in humans is encoded by the ''PEX11A'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generat ...

, PEX11B,

PEX11G PEX11G is a human gene that encodes the peroxisomal biogenesis factor 11 gamma for peroxisomes. It is located on chromosome 19 Chromosome 19 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chro ...

* PEX12 *

PEX13 Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the ''PEX13'' gene. It located on chromosome 2 next to KIAA1841 Interactions PEX13 has been shown to interact with PEX14, PEX5 and PEX19 Peroxisomal biogenesis fact ...

PEX14 Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the ''PEX14'' gene. Function This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with i ...

* PEX16 * PEX19 * PEX26

References

Gene families Transmembrane proteins {{biochem-stub