''Percavirus'' is a genus of
viruses
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea.
Since Dmitri Ivanovsky's 1 ...
in the order ''
Herpesvirales
The ''Herpesvirales'' is an order of dsDNA viruses (Baltimore group I) with animal hosts, characterised by a common morphology consisting of an icosahedral capsid enclosed in a glycoprotein-containing lipid envelope. Common infections in humans c ...
'', in the family ''
Herpesviridae
''Herpesviridae'' is a large family of DNA viruses that cause infections and certain diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word ''ἕρπειν ...
'', in the subfamily ''
Gammaherpesvirinae
''Gammaherpesvirinae'' is a subfamily of viruses in the order ''Herpesvirales'' and in the family ''Herpesviridae''. Viruses in ''Gammaherpesvirinae'' are distinguished by reproducing at a more variable rate than other subfamilies of ''Herpesvir ...
''. Mammals serve as natural hosts. There are six species in this genus. Diseases associated with this genus include:
conjunctivitis
Conjunctivitis, also known as pink eye, is inflammation of the conjunctiva, outermost layer of the white part of the eye and the inner surface of the eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may ...
,
immunosuppression
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse react ...
in foals, pneumonia, respiratory disease.
Species
The genus consists of the following six species:
* ''
Equid gammaherpesvirus 2''
* ''
Equid gammaherpesvirus 5''
* ''
Felid gammaherpesvirus 1''
* ''
Mustelid gammaherpesvirus 1''
* ''
Phocid gammaherpesvirus 3''
* ''
Vespertilionid gammaherpesvirus 1''
Structure
Viruses in ''Percavirus'' are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry. The diameter is around 150-200 nm. Genomes are linear and non-segmented, around 180kb in length.
Life cycle
Viral replication is nuclear, and is lysogenic. Entry into the host cell is achieved by attachment of the viral glycoproteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and budding.
Mammals serve as the natural host.
References
External links
Viralzone: ''Percavirus''ICTV
{{Taxonbar, from=Q18813565
Herpesviridae
Virus genera