Paul M. Lieberman is an American biomedical researcher and chairperson of the Gene Expression and Regulation Program at the Ellen and Ronald Caplan Cancer Center at The Wistar Institute in

Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Sinc ...

. He is also the

Hilary Koprowski Hilary Koprowski (5 December 191611 April 2013) was a Polish virologist and immunologist active in the United States who demonstrated the world's first effective live polio vaccine. He authored or co-authored over 875 scientific papers and co ...

, M.D., endowed professor, the McNeil professor of Molecular Medicine and Translational Research, and the founding director for the Center for Chemical Biology and Translational Medicine at The Wistar Institute. Lieberman's research focuses on how viruses cause cancer and autoimmune disease, particularly the

Epstein–Barr virus The Epstein–Barr virus (EBV), formally called ''Human gammaherpesvirus 4'', is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. It is b ...

Education

He earned a BA in chemistry from

Cornell University Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach an ...

(1983) and a Ph.D. in molecular virology from

Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...

(1989).

Career and research

Lieberman and his laboratory have facilitated the development of the first annotated atlas of the Epstein-Barr virus epigenome. In 2011, Lieberman received a Seeding Drug Discovery Award from

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...

for $4.7 million to develop a drug against Epstein-Barr virus-related cancers. This was the first project to receive such an award from the United Kingdom-based trust. He also leads a team developing a drug to treat Epstein-Barr virus-related cancers. This project received a United Kingdom-based Wellcome Trust Seeding Drug Discovery. Lieberman previously served as the president of the International Association for Research on Epstein-Barr Virus and Associated Diseases and is an elected fellow of the American Association for the Advancement of Sciences (AAAS).

Select publications

* * * * * * Deng Z, Glousker G, et al., Lieberman PM, Tzfati, Y. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. PNAS 2013. * Dheekollu J, Chen HS, Kaye KM, Lieberman PM. Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. Journal of Virology. 2013 Apr 87(7):369. * Deng Z, Wang Z, Stong N, Plasschaert R, et al. Riethman H, and Lieberman PM. A role for CTCF and cohesion in subtelomere chromatin organization, TERRA transcription, and telomere end protection. EMBO J. 2012 Nov 31(21):4165. * Kang H, Cho H, Sung GH, Lieberman PM. CTCF regulates Kaposi's sarcoma-associated herpesvirus latency transcription by nucleosome displacement and RNA polymerase programming. Journal of Virology 2013 Feb 87(3)1789. * Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova N, Klichinsky M, Leslie C, Lieberman PM. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe 2012 Aug 12(2)233.

References

External links

Dr. Lieberman's lab page on The Wistar Institute's website
* {{DEFAULTSORT:Lieberman, Paul Cancer researchers Living people Year of birth missing (living people) Cornell University alumni Johns Hopkins School of Medicine alumni American virologists American medical researchers