Sir Paul Gordon Fildes (10 February 1882 – 5 February 1971) was a British
pathologist
Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...
and
microbiologist
A microbiologist (from Ancient Greek, Greek ) is a scientist who studies microscopic life forms and processes. This includes study of the growth, interactions and characteristics of Microorganism, microscopic organisms such as bacteria, algae, f ...
who worked on the development of chemical-
biological weapon
A biological agent (also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon) is a bacterium, virus, protozoan, parasite, fungus, or toxin that can be used purposefully as a weapon in bioterroris ...
ry at
Porton Down
Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl ...
during the
Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
.
[Fellow list of the Royal Society](_blank)
/ref>
Biography
Early life
Fildes was born in Kensington, London, the son of the artist Sir Luke Fildes
__NOTOC__
Sir Samuel Luke Fildes (3 October 1843 – 28 February 1927) was a British painter and illustrator born in Liverpool and trained at the South Kensington and Royal Academy Schools. He was the grandson of the political activist Mar ...
and great grandson of reformist Mary Fildes
Mary Fildes was president of the Manchester Female Reform Society in 1819, and played a leading role at the mass rally at Manchester in that year which ended in the Peterloo massacre. She was also the grandmother of the artist Luke Fildes thr ...
, Paul attended Winchester School
Winchester College is a public school (fee-charging independent day and boarding school) in Winchester, Hampshire, England. It was founded by William of Wykeham in 1382 and has existed in its present location ever since. It is the oldest of t ...
and then studied surgery at Trinity College, Cambridge
Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by Henry VIII, King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge ...
, where he obtained an MB BCh
Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United Kin ...
degree.
Career
Fildes served as a lieutenant-commander
Lieutenant commander (also hyphenated lieutenant-commander and abbreviated Lt Cdr, LtCdr. or LCDR) is a commissioned officer rank in many navies. The rank is superior to a lieutenant and subordinate to a commander. The corresponding rank i ...
in the Royal Naval Volunteer Reserve
Royal may refer to:
People
* Royal (name), a list of people with either the surname or given name
* A member of a royal family
Places United States
* Royal, Arkansas, an unincorporated community
* Royal, Illinois, a village
* Royal, Iowa, a cit ...
, stationed at the Royal Naval Hospital Haslar
The Royal Hospital Haslar in Gosport, Hampshire, was one of several hospitals serving the local area. It was converted into retirement flats between 2018 and 2020. The hospital itself is a Grade II listed building.
History
Formation and ope ...
(1915–19) during the First World War
World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...
. In 1919 he was made an Officer of the Order of the British Empire
The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations,
and public service outside the civil service. It was established o ...
.
After working at the London Hospital
The Royal London Hospital is a large teaching hospital in Whitechapel in the London Borough of Tower Hamlets. It is part of Barts Health NHS Trust. It provides district general hospital services for the City of London and Tower Hamlets and spe ...
as an assistant bacteriologist, he moved in 1934 to work at the Middlesex Hospital
Middlesex Hospital was a teaching hospital located in the Fitzrovia area of London, England. First opened as the Middlesex Infirmary in 1745 on Windmill Street, it was moved in 1757 to Mortimer Street where it remained until it was finally clos ...
. He was also elected a Fellow of the Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
in 1934.
In 1940 he helped Donald D. Woods discover how sulphonamides
In organic chemistry, the sulfonamide functional group (also spelled sulphonamide) is an organosulfur group with the structure . It consists of a sulfonyl group () connected to an amine group (). Relatively speaking this group is unreactive. B ...
worked.
He was a member of the scientific staff, Medical Research Council (1934–49).
World War II
Fildes asserted that he assisted with Operation Anthropoid
On 27 May 1942 in Prague, Reinhard Heydrichthe commander of the Reich Security Main Office (RSHA), acting governor of the Protectorate of Bohemia and Moravia, and a principal architect of the Holocaustwas attacked and wounded in an assassinatio ...
the assassination of top Nazi Reinhard Heydrich
Reinhard Tristan Eugen Heydrich ( ; ; 7 March 1904 – 4 June 1942) was a high-ranking German SS and police official during the Nazi era and a principal architect of the Holocaust.
He was chief of the Reich Security Main Office (inclu ...
in Prague by providing the Czech
Czech may refer to:
* Anything from or related to the Czech Republic, a country in Europe
** Czech language
** Czechs, the people of the area
** Czech culture
** Czech cuisine
* One of three mythical brothers, Lech, Czech, and Rus'
Places
*Czech, ...
agents of the Special Operations Executive
The Special Operations Executive (SOE) was a secret British World War II organisation. It was officially formed on 22 July 1940 under Minister of Economic Warfare Hugh Dalton, from the amalgamation of three existing secret organisations. Its pu ...
with modified No. 73 Grenades filled with botulin toxin
Botulinum toxin, or botulinum neurotoxin (BoNT), is a neurotoxic protein produced by the bacterium ''Clostridium botulinum'' and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromusc ...
. The story has been met with scepticism, given the absence of any indication that Heydrich displayed any of the highly distinctive symptoms of botulism
Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium ''Clostridium botulinum''. The disease begins with weakness, blurred vision, feeling tired, and trouble speaking. This may then be followed by weaknes ...
.
In 1940 Fildes was put in charge of a newly created department, the Biology Department, Porton (BDP) at Porton Down
Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl ...
to study the defensive implications of a bacterial attack and there built up a team of microbiologists to study the use of biological weapons, including anthrax and botulinum toxin. An early project was the creation of a stockpile of a million anthrax impregnated cattle cakes to be used in a possible retaliatory attack. In 1942 it famously carried out tests of an anthrax bio-weapon developed at Porton Down at Gruinard Island
Gruinard Island ( ;
gd, Eilean Ghruinneard) is a small, oval-shaped Scottish island approximately long by wide, located in Gruinard Bay, about halfway between Gairloch and Ullapool. At its closest point to the mainland, it is about offshore ...
. He also assisted with the anthrax
Anthrax is an infection caused by the bacterium ''Bacillus anthracis''. It can occur in four forms: skin, lungs, intestinal, and injection. Symptom onset occurs between one day and more than two months after the infection is contracted. The sk ...
strain tests on Gruinard Island
Gruinard Island ( ;
gd, Eilean Ghruinneard) is a small, oval-shaped Scottish island approximately long by wide, located in Gruinard Bay, about halfway between Gairloch and Ullapool. At its closest point to the mainland, it is about offshore ...
, performing necropsies on the bodies of anthrax-exposed sheep, to determine if they had died as a direct result of anthrax poisoning. This work produced the world's first working anthrax bomb in the summer of 1942.
At the end of the war he returned to university life and handed over control of the department to his deputy David Henderson, who oversaw the building of a new purpose designed laboratory facility and the creation of the autonomous Microbiological Research Department. He was knighted in the 1946 New Year Honours
The 1946 New Year Honours were appointments by many of the Commonwealth Realms of King George VI to various orders and honours to reward and highlight good works by citizens of those countries, and to celebrate the passing of 1945 and the beginnin ...
.
Later years
After the war Fildes worked at the Sir William Dunn School of Pathology
The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergra ...
in Oxford, headed by Nobel Prize winner Sir Howard Florey
Howard Walter Florey, Baron Florey (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Chain and Sir Alexander Fleming for his role in ...
, to study on the biochemistry of bacteriophage T1 (and to a lesser extent, T2) multiplication.
Fildes received the Copley Medal
The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...
in 1963 from the Royal Society.
Works
He was the author of works on haemophilia
Haemophilia, or hemophilia (), is a mostly inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. This results in people bleeding for a longer time after an injury, easy bruising, ...
and syphilis
Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, an ...
.
References
{{DEFAULTSORT:Fildes, Paul
1882 births
1971 deaths
People educated at Winchester College
Alumni of Trinity College, Cambridge
British microbiologists
Fellows of the Royal Society
Recipients of the Copley Medal
Royal Naval Volunteer Reserve personnel of World War II
Knights Bachelor
Royal Medal winners
Place of birth missing
Officers of the Order of the British Empire