Paul B. Sigler ( –
/ref>) was the Henry Ford II Professor of Molecular Biophysics and

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...

. Major awards included membership in the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

HHMI The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

Investigator status, and Guggenheim and

Helen Hay Whitney Helen Julia Hay Whitney (March 11, 1875 – September 24, 1944) was an American poet, writer, racehorse owner/breeder, socialite, and philanthropist. She was a member by marriage of the prominent Whitney family of New York. Early life She was ...

Fellowships. He is noted for pioneering studies of

Phospholipase A2 The enzyme phospholipase A2 (EC 3.1.1.4, PLA2, systematic name phosphatidylcholine 2-acylhydrolase) catalyse the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid “tail” and the glyce ...

and trp repressor amongst many others.

Biography

Prior to coming to Yale, he was a professor at the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

. He received his MD from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

in 1959 and his undergraduate degree from

Princeton University Princeton University is a private university, private research university in Princeton, New Jersey. Founded in 1746 in Elizabeth, New Jersey, Elizabeth as the College of New Jersey, Princeton is the List of Colonial Colleges, fourth-oldest ins ...

in 1955. After briefly practicing medicine and working as a researcher for the NIH, he would go on to earn a second doctorate, a PhD, from

Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

at the Laboratory of Molecular Biology working under

David M. Blow David Mervyn Blow (27 June 1931 – 8 June 2004) was an influential British biophysicist. He was best known for the development of X-ray crystallography, a technique used to determine the molecular structures of tens of thousands of biologica ...

before moving to the University of Chicago.

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of

. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry. Yale also has sponsored Paul Sigler memorial symposia in the past. The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.

Death

Paul Sigler died on January 11, 2000 at

New Haven, Connecticut New Haven is a city in the U.S. state of Connecticut. It is located on New Haven Harbor on the northern shore of Long Island Sound in New Haven County, Connecticut and is part of the New York City metropolitan area. With a population of 134,02 ...

, US, 39 days before his 66th birthday.

Selected publications

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References

External links

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Paul B. Sigler on AcademicTree
{{DEFAULTSORT:Sigler, Paul B. Princeton University alumni American biophysicists American biochemists Yale University faculty University of Chicago faculty Yale Department of Molecular Biophysics & Biochemistry faculty Scientists from New Haven, Connecticut People from Chicago Scientists from New York City People from Cambridge People from Princeton, New Jersey People from Washington, D.C. People from Richmond, Virginia Members of the United States National Academy of Sciences Howard Hughes Medical Investigators 1934 births 2000 deaths Columbia University Vagelos College of Physicians and Surgeons alumni Alumni of the University of Cambridge Physicians from New Haven, Connecticut Scientists from Virginia