genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In the hierarchy of biological classification, genus com ...
of
parasitic
Parasitism is a close relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life. The entomologist E. O. Wilson has c ...
flatworm
The flatworms, flat worms, Platyhelminthes, or platyhelminths (from the Greek πλατύ, ''platy'', meaning "flat" and ἕλμινς (root: ἑλμινθ-), ''helminth-'', meaning "worm") are a phylum of relatively simple bilaterian, unsegment ...
s belonging to the
digenetic
Digenea (Gr. ''Dis'' – double, ''Genos'' – race) is a class of trematodes in the Platyhelminthes phylum, consisting of parasitic flatworms (known as ''flukes'') with a syncytial tegument and, usually, two suckers, one ventral and one oral ...
trematodes. It includes flukes which are mostly parasitising
livestock
Livestock are the domesticated animals raised in an agricultural setting to provide labor and produce diversified products for consumption such as meat, eggs, milk, fur, leather, and wool. The term is sometimes used to refer solely to animals ...
ruminants
Ruminants ( suborder Ruminantia) are hoofed herbivorous grazing or browsing mammals that are able to acquire nutrients from plant-based food by fermenting it in a specialized stomach prior to digestion, principally through microbial actions. The ...
, as well as some wild
mammals
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or ...
. They are responsible for the serious disease called paramphistomiasis, also known as amphistomosis, especially in
cattle
Cattle (''Bos taurus'') are large, domesticated, cloven-hooved, herbivores. They are a prominent modern member of the subfamily Bovinae and the most widespread species of the genus ''Bos''. Adult females are referred to as cows and adult mal ...
and
sheep
Sheep or domestic sheep (''Ovis aries'') are domesticated, ruminant mammals typically kept as livestock. Although the term ''sheep'' can apply to other species in the genus ''Ovis'', in everyday usage it almost always refers to domesticated s ...
. Its
symptoms
Signs and symptoms are the observed or detectable signs, and experienced symptoms of an disease, illness, injury, or condition. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormali ...
include profuse
diarrhoea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin wi ...
,
anaemia
Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, th ...
,
lethargy
Lethargy is a state of tiredness, sleepiness, weariness, fatigue, sluggishness or lack of energy. It can be accompanied by depression, decreased motivation, or apathy. Lethargy can be a normal response to inadequate sleep, overexertion, overwo ...
, and often result in death if untreated. They are found throughout the world, and most abundantly in
livestock
Livestock are the domesticated animals raised in an agricultural setting to provide labor and produce diversified products for consumption such as meat, eggs, milk, fur, leather, and wool. The term is sometimes used to refer solely to animals ...
farming
Agriculture or farming is the practice of cultivating plants and livestock. Agriculture was the key development in the rise of sedentary human civilization, whereby farming of domesticated species created food surpluses that enabled people to ...
regions such as
Australia
Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, sma ...
,
Asia
Asia (, ) is one of the world's most notable geographical regions, which is either considered a continent in its own right or a subcontinent of Eurasia, which shares the continental landmass of Afro-Eurasia with Africa. Asia covers an area ...
,
Africa
Africa is the world's second-largest and second-most populous continent, after Asia in both cases. At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 6% of Earth's total surface area ...
,
Eastern Europe
Eastern Europe is a subregion of the Europe, European continent. As a largely ambiguous term, it has a wide range of geopolitical, geographical, ethnic, cultural, and socio-economic connotations. The vast majority of the region is covered by Russ ...
, and
Russia
Russia (, , ), or the Russian Federation, is a List of transcontinental countries, transcontinental country spanning Eastern Europe and North Asia, Northern Asia. It is the List of countries and dependencies by area, largest country in the ...
.
The
generic
Generic or generics may refer to:
In business
* Generic term, a common name used for a range or class of similar things not protected by trademark
* Generic brand, a brand for a product that does not have an associated brand or trademark, other ...
name was introduced by F. Fischoeder in 1901 for the replacement of the then existing genus ''Amphistoma'' (Rudolphi, 1809). Under the new genus he redescribed both ''
Paramphistomum cervi
''Paramphistomum cervi'', the type species of ''Paramphistomum'', is a parasitic flat worm belonging to the class Trematoda. It is a tiny fluke mostly parasitising livestock ruminants, as well as some wild mammals. Uniquely, unlike most parasit ...
'' and ''P. bothriophoron'' and designated the former as the
type species
In zoological nomenclature, a type species (''species typica'') is the species name with which the name of a genus or subgenus is considered to be permanently taxonomically associated, i.e., the species that contains the biological type specimen ...
.
Species
Due to striking resemblance with each other and with other amphistomes, a number of described species are known to be synonymous. Some important species are:
*''
Paramphistomum cervi
''Paramphistomum cervi'', the type species of ''Paramphistomum'', is a parasitic flat worm belonging to the class Trematoda. It is a tiny fluke mostly parasitising livestock ruminants, as well as some wild mammals. Uniquely, unlike most parasit ...
''
*''
Paramphistomum cotylophorum
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum cracile
''Paramphistomum'' is a genus of parasitic flatworms belonging to the digenetic trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for the serious disease called ...
''
*''
Paramphistomum gotoi
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum grande
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum hiberniae
''Paramphistomum'' is a genus of parasitic flatworms belonging to the digenetic trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for the serious disease called ...
''
*''
Paramphistomum ichikawai
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum epiclitum
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum explanatum
''Paramphistomum'' is a genus of parasitic flatworms belonging to the digenetic trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for the serious disease called ...
''
*''
Paramphistomum leydeni
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum liorchis
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
*''
Paramphistomum microbothrioides
''Paramphistomum'' is a genus of parasitic flatworms belonging to the digenetic trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for the serious disease called ...
''
*''
Paramphistomum phillerouxi
''Paramphistomum'' is a genus of Parasite, parasitic flatworms belonging to the Digenea, digenetic Trematoda, trematodes. It includes flukes which are mostly parasitising livestock ruminants, as well as some wild mammals. They are responsible for ...
''
Description
The generic name (
Greek
Greek may refer to:
Greece
Anything of, from, or related to Greece, a country in Southern Europe:
*Greeks, an ethnic group.
*Greek language, a branch of the Indo-European language family.
**Proto-Greek language, the assumed last common ancestor ...
: ''para'' meaning "similar" o ''Amphistoma'' ''amphi'' meaning "on both sides", and ''stoma'' for "mouth") is given due to the presence of an anterior oral sucker and a posterior larger ventral sucker in adult worms. The body is minute, measuring less than a
centimetre
330px, Different lengths as in respect to the Electromagnetic spectrum, measured by the Metre and its deriveds scales. The Microwave are in-between 1 meter to 1 millimeter.
A centimetre (international spelling) or centimeter (American spellin ...
. The body is covered with a highly folded tegument, which in turn is provided with sensory papillae. ''Paramphistomum'' are all
hermaphrodite
In reproductive biology, a hermaphrodite () is an organism that has both kinds of reproductive organs and can produce both gametes associated with male and female sexes.
Many Taxonomy (biology), taxonomic groups of animals (mostly invertebrate ...
, having both male and female
reproductive system
The reproductive system of an organism, also known as the genital system, is the biological system made up of all the anatomical organs involved in sexual reproduction. Many non-living substances such as fluids, hormones, and pheromones are als ...
s in the posterior region of the body.
Life cycle
Their
life cycle
Life cycle, life-cycle, or lifecycle may refer to:
Science and academia
*Biological life cycle, the sequence of life stages that an organism undergoes from birth to reproduction ending with the production of the offspring
*Life-cycle hypothesis, ...
is indirect, requiring a
definitive host
In biology and medicine, a host is a larger organism that harbours a smaller organism; whether a parasitic, a mutualistic, or a commensalist ''guest'' (symbiont). The guest is typically provided with nourishment and shelter. Examples include a ...
such as
ruminants
Ruminants ( suborder Ruminantia) are hoofed herbivorous grazing or browsing mammals that are able to acquire nutrients from plant-based food by fermenting it in a specialized stomach prior to digestion, principally through microbial actions. The ...
, an
intermediate host
In biology and medicine, a host is a larger organism that harbours a smaller organism; whether a parasitic, a mutualistic, or a commensalist ''guest'' (symbiont). The guest is typically provided with nourishment and shelter. Examples include a ...
such as
snail
A snail is, in loose terms, a shelled gastropod. The name is most often applied to land snails, terrestrial pulmonate gastropod molluscs. However, the common name ''snail'' is also used for most of the members of the molluscan class Gastro ...
, and a free-living of external phases in water and plants. The sexually mature
monoecious
Monoecy (; adj. monoecious ) is a sexual system in seed plants where separate male and female cones or flowers are present on the same plant. It is a monomorphic sexual system alongside gynomonoecy, andromonoecy and trimonoecy.
Monoecy is conne ...
rumen
The rumen, also known as a paunch, is the largest stomach compartment in ruminants and the larger part of the reticulorumen, which is the first chamber in the alimentary canal of ruminant animals. The rumen's microbial favoring environment allow ...
, and release the eggs along with
faeces
Feces ( or faeces), known colloquially and in slang as poo and poop, are the solid or semi-solid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine. Feces contain a relati ...
. Eggs hatch in water into ciliated
miracidia
Trematodes are parasitic flatworms of the class ''Trematoda'', specifically parasitic flukes with two suckers: one ventral and the other oral. Trematodes are covered by a tegument, that protects the organism from the environment by providing sec ...
. The miracidia then enters the body of an intermediate host, which are snails belonging to the
genera
Genus ( plural genera ) is a taxonomic rank used in the biological classification of living and fossil organisms as well as viruses. In the hierarchy of biological classification, genus comes above species and below family. In binomial nomenclat ...
''
Bulinus
''Bulinus'' is a genus of small tropical freshwater snails, aquatic gastropod mollusks in the family Bulinidae, the ramshorn snails and their allies. MolluscaBase eds. (2020). MolluscaBase. Bulinus O. F. Müller, 1781. Accessed through: Worl ...
'', ''
Planorbis
''Planorbis'' is a genus of air-breathing freshwater snails, aquatic pulmonate gastropod mollusks in the family Planorbidae, the ram's horn snails, or planorbids. All species in this genus have sinistral or left-coiling shells.Bouchet, P.; Rosen ...
'', ''
Physa
''Physa'' is a genus of small, left-handed or sinistral, air-breathing freshwater snails, aquatic pulmonate gastropod mollusks in the subfamily Physinae of the family Physidae.MolluscaBase eds. (2021). MolluscaBase. Physa Draparnaud, 1801. Ac ...
'' ''
Stagnicola
''Stagnicola'' is a genus of air-breathing freshwater snails, aquatic pulmonate gastropod mollusks in the family Lymnaeidae, the pond snails.Bouchet, P.; Rosenberg, G. (2014). Stagnicola Jeffreys, 1830. Accessed through: World Register of Mari ...
'' and ''
Pseudosuccinea
''Pseudosuccinea'' is a genus of air-breathing freshwater snails, Aquatic animal, aquatic pulmonate gastropod mollusks in the family Lymnaeidae, the pond snails.
In this genus, the gastropod shell, shells are very similar to those of the land s ...
''. Then the miracidia lost their cilia to become sporocysts. After a few days they develop up to 8 rediae, which are rapidly liberated. Each redia contains about 15-30
cercariae
Trematodes are parasitic flatworms of the class ''Trematoda'', specifically parasitic flukes with two suckers: one ventral and the other oral. Trematodes are covered by a tegument, that protects the organism from the environment by providing secr ...
. Mature cercariae are possess by two eyespots and a long slender tail, by which they find aquatic plants or other suitable substrata, to which they get attached and
encyst
A microbial cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. It can be thought of as a state of ...
to become
metacercariae
Trematodes are parasitic flatworms of the class ''Trematoda'', specifically parasitic flukes with two suckers: one ventral and the other oral. Trematodes are covered by a tegument, that protects the organism from the environment by providing secr ...
. The mammalian hosts ingest the infective larvae. Once inside the
duodenum
The duodenum is the first section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear, and the terms anterior intestine or proximal intestine m ...
and
jejunum
The jejunum is the second part of the small intestine in humans and most higher vertebrates, including mammals, reptiles, and birds. Its lining is specialised for the absorption by enterocytes of small nutrient molecules which have been previous ...
, their
cyst
A cyst is a closed sac, having a distinct envelope and cell division, division compared with the nearby Biological tissue, tissue. Hence, it is a cluster of Cell (biology), cells that have grouped together to form a sac (like the manner in which ...
s are removed. They penetrate the intestinal wall by actively destroying the
mucosa
A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is ...
, and then migrate to the rumen, where the grow into adult.
Pathogenicity and pathology
Paramphistomiasis causes enteritis and anaemia in livestock mammals and result in substantial production and economic losses. Pathological symptoms are produced by immature flukes. When the young flukes start to gather in the intestine, there is a watery and fetid diarrhoea which is often associated with high mortality (even up to 80-90%) in ruminants. At a given time, as many as 30,000 flukes may accumulate, fervently attacking the duodenal mucosa to induce acute enteritis. Adult flukes are relatively harmless. Liver tissue are generally damaged extensively, indicated by swelling,
haemorrhage
Bleeding, hemorrhage, haemorrhage or blood loss, is blood escaping from the circulatory system from damaged blood vessels. Bleeding can occur internally, or externally either through a natural opening such as the mouth, nose, ear, urethra, vagi ...
, discolouration,
necrosis
Necrosis () is a form of cell injury which results in the premature death of cells in living tissue by autolysis. Necrosis is caused by factors external to the cell or tissue, such as infection, or trauma which result in the unregulated dige ...
, bile duct
hyperplasia
Hyperplasia (from ancient Greek ὑπέρ ''huper'' 'over' + πλάσις ''plasis'' 'formation'), or hypergenesis, is an enlargement of an organ or tissue caused by an increase in the amount of organic tissue that results from cell proliferati ...
, and
fibrosis
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of perma ...
.
Diagnosis and treatment
Symptoms are easily indicated by infected sheep and cattle as they become severely
anorexic
Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin. ''Anorexia'' is a term of Gre ...
or inefficiently digest food, and become unthrifty. Fetid diarrhoea is an obvious indication so that fluid faeces are examined for immature flukes.
Paramphistomiasis is considered a neglected
tropical disease
Tropical diseases are Infectious disease, diseases that are prevalent in or unique to tropics, tropical and subtropics, subtropical regions. The diseases are less prevalent in temperate climates, due in part to the occurrence of a cold season, whic ...
, with no prescription drug for treatment and control. Thus management of infection is based mainly on control of the snail population. Drugs shown to be effective are resorantel,
oxyclozanide
Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes. Alon ...
, clorsulon,
ivermectin
Ivermectin (, '' EYE-vər-MEK-tin'') is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, today it is used to treat inf ...
,
niclosamide
Niclosamide, sold under the brand name Niclocide among others, is an anthelmintic medication used to treat tapeworm infestations, including diphyllobothriasis, hymenolepiasis, and taeniasis. It is not effective against other worms such as flukes ...
, bithional and
levamisole
Levamisole, sold under the brand name Ergamisol among others, is a medication used to treat parasitic worm infections, specifically ascariasis and hookworm infections. It is taken by mouth.
Side effects may include abdominal pain, vomiting, he ...