Papuamides A and B are

depsipeptides A depsipeptide is a peptide in which one or more of its amide, -C(O)NHR-, groups are replaced by the corresponding ester, -C(O)OR, Many depsipeptides have both peptide and ester linkages. Elimination of the N–H group in a peptide structure results ...

which appear to protect T cells from

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

. They were isolated from the

sponge Sponges, the members of the phylum Porifera (; meaning 'pore bearer'), are a basal animal clade as a sister of the diploblasts. They are multicellular organisms that have bodies full of pores and channels allowing water to circulate through t ...

Theonella, and are part of a larger group of structurally similar depsipeptides—also isolated from sponges—including

neamphamide A Neamphamide A is an HIV-inhibitory isolate of the sea sponge '' Neamphius huxleyi''. References Depsipeptides {{organic-compound-stub ...

callipeltin A Callipeltin A & B Callipeltin A and B are bio-active isolates of marine invertebrates. See also * Depsipeptide * Papuamide Papuamides A and B are depsipeptides which appear to protect T cells A T cell is a type of lymphocyte. T cells are one of ...

, and mirabamides A-D.

References

Depsipeptides {{organic-compound-stub