Panayotis G. Katsoyannis (January 7, 1924 - May 31, 2019) was an American

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

who is often credited with being the first to synthesize

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...

while leading a team at the

University of Pittsburgh The University of Pittsburgh (Pitt) is a public state-related research university in Pittsburgh, Pennsylvania. The university is composed of 17 undergraduate and graduate schools and colleges at its urban Pittsburgh campus, home to the universit ...

in the early 1960s. His results synthesizing insulin were achieved almost simultaneously with that of

Helmut Zahn Helmut Zahn (born June 13, 1916 in Erlangen; died November 14, 2004 in Aachen) was a German chemist who is often credited as the first to synthesize Insulin in 1963. His results synthesizing insulin were achieved almost simultaneously with that of ...

RWTH Aachen University RWTH Aachen University (), also known as North Rhine-Westphalia Technical University of Aachen, Rhine-Westphalia Technical University of Aachen, Technical University of Aachen, University of Aachen, or ''Rheinisch-Westfälische Technische Hoch ...

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

. In his early years, while doing his PhD at the

University of Athens The National and Kapodistrian University of Athens (NKUA; el, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών, ''Ethnikó ke Kapodistriakó Panepistímio Athinón''), usually referred to simply as the Univers ...

Katsoyannis had been under the mentorship of

Leonidas Zervas Leonidas Zervas ( el, Λεωνίδας Ζέρβας, ; 21 May 1902 – 10 July 1980) was a Greek organic chemist who made seminal contributions in peptide chemical synthesis. Together with his mentor Max Bergmann they laid the foundations for t ...

, who previously developed new synthetic methods for asymmetric cysteine-containing peptides as those in insulin. Katsoyannis was also noted for his studies on the synthesis of

oxytocin Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin ...

and

vasopressin Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then travel ...

. Following his time at the University of Pittsburgh, Katsoyannis served as the Head of the Division of Biochemistry at the

Brookhaven National Laboratory Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment c ...

and later was appointed as the founding Chairman of the Department of Biochemistry at

Mount Sinai School of Medicine The Icahn School of Medicine at Mount Sinai (ISMMS or Mount Sinai), formerly the Mount Sinai School of Medicine, is a private medical school in New York City. It is the academic teaching arm of the Mount Sinai Health System, which manages eigh ...

in 1967 where he remained until the end of his life, in later years as Distinguished Service Professor and Chair Emeritus in Pharmacologic and Systems Therapeutics. Katoyannis received the Commemorative Medallion of the

American Diabetes Association The American Diabetes Association (ADA) is a United States-based nonprofit that seeks to educate the public about diabetes and to help those affected by it through funding research to manage, cure and prevent diabetes (including type 1 diabetes, ...

in 1972 on the fiftieth anniversary of the discovery of insulin. He also received the Jacobi Medallion from Mount Sinai Alumni in 1995 and an honorary degree from the

University of Patras The University of Patras (UPatras; el, Πανεπιστήμιο Πατρών, ''Panepistímio Patrón'') is a public university in Patras, Greece. It is the third-largest university in Greece with respect to the size of the student body, the s ...

Greece Greece,, or , romanized: ', officially the Hellenic Republic, is a country in Southeast Europe. It is situated on the southern tip of the Balkans, and is located at the crossroads of Europe, Asia, and Africa. Greece shares land borders with ...

in 1997. He is a Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

(1966), the

New York Academy of Sciences The New York Academy of Sciences (originally the Lyceum of Natural History) was founded in January 1817 as the Lyceum of Natural History. It is the fourth oldest scientific society in the United States. An independent, nonprofit organization wit ...

(1977), and a Corresponding Member of the National Academy of Greece (Academy of Athens) (1966). Katoyannis died on May 31, 2019 at the age of 95.

References

{{DEFAULTSORT:Katsoyannis, Panayotis American biochemists American people of Greek descent University of Pittsburgh faculty Icahn School of Medicine at Mount Sinai faculty 2019 deaths 1924 births Brookhaven National Laboratory staff National and Kapodistrian University of Athens alumni