Panacea Biotec is an Indian multinational global

generic Generic or generics may refer to: In business * Generic term, a common name used for a range or class of similar things not protected by trademark * Generic brand, a brand for a product that does not have an associated brand or trademark, other ...

and

specialty pharmaceutical Specialty or speciality may refer to: * Deed, a contract in law * Index of speciality, a geometrical invariant * Speciality (album), ''Speciality'' (album), an album by J-Pop singer Nami Tamaki * Specialty (medicine), a field within medicine * Spec ...

and

vaccine A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verifie ...

maker. It has principal offices in

New Delhi New Delhi (, , ''Naī Dillī'') is the capital of India and a part of the National Capital Territory of Delhi (NCT). New Delhi is the seat of all three branches of the government of India, hosting the Rashtrapati Bhavan, Parliament House ...

Mumbai Mumbai (, ; also known as Bombay — the official name until 1995) is the capital city of the Indian state of Maharashtra and the ''de facto'' financial centre of India. According to the United Nations, as of 2018, Mumbai is the second- ...

, and Lalru (near

Chandigarh Chandigarh () is a planned city in India. Chandigarh is bordered by the state of Punjab to the west and the south, and by the state of Haryana to the east. It constitutes the bulk of the Chandigarh Capital Region or Greater Chandigarh, which al ...

). It has business interests in research, development, manufacturing and marketing of pharmaceutical formulations,

s, biosimilars, and natural products.

History

Panacea Drugs was set up in the year 1984 and got listed in 1995 as Panacea Biotec Ltd. The company has grown organically to become one of the largest vaccine manufacturers in India. In August 2011, several of its

hepatitis Hepatitis is inflammation of the liver tissue. Some people or animals with hepatitis have no symptoms, whereas others develop yellow discoloration of the skin and whites of the eyes (jaundice), poor appetite, vomiting, tiredness, abdominal pa ...

vaccines were removed from the list of prequalified vaccines by the

World Health Organization The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level of h ...

because of quality management issues, but the issues were resolved by early 2012. Its leading product, EasyFive-TT, regained WHO PQ in September 2013. As of July 2020, the company is also developing a vaccine for

SARS-COV-2 Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19 (coronavirus disease 2019), the respiratory illness responsible for the ongoing COVID-19 pandemic. The virus previously had a ...

using a Whole inactivated Virus approach. It got an investment in April 2020 from a US based pharma firm. In May 2021, Panacea Biotec tied up with

Russian Direct Investment Fund The Russian Direct Investment Fund (RDIF) is Russia's sovereign wealth fund established in 2011 by the Russian government to make investments in companies of high-growth sectors of the Russian economy. Its mandate is to co-invest alongside the wo ...

(RDIF, Russia’s sovereign wealth fund) to produce 100 million doses of

Sputnik V COVID-19 vaccine Sputnik V (russian: Спутник V, the brand name from RDIF) or Gam-COVID-Vac (russian: Гам-КОВИД-Вак, the name under which it is legally registered and produced) is an adenovirus viral vector vaccine for COVID-19 developed by t ...

annually in India.

Products

Panacea Biotec is one of the largest vaccine manufacturers and pharmaceutical companies in India. Panacea Biotec is focused on research in Vaccines, Pharmaceuticals, Biosimilars, and Nutraceuticals. It is one of the three largest

biotechnology Biotechnology is the integration of natural sciences and engineering sciences in order to achieve the application of organisms, cells, parts thereof and molecular analogues for products and services. The term ''biotechnology'' was first used b ...

companies in India. The company develops and produces medicines for a wide range of medical disciplines, including

oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ó ...

organ transplant Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transpo ...

immunology Immunology is a branch of medicineImmunology for Medical Students, Roderick Nairn, Matthew Helbert, Mosby, 2007 and biology that covers the medical study of immune systems in humans, animals, plants and sapient species. In such we can see there ...

and

pain management Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professionals pr ...

gastroenterology Gastroenterology (from the Greek gastḗr- “belly”, -énteron “intestine”, and -logía "study of") is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract ...

s, and diabetology/

endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

Transplant

Panacea Biotec has many drugs for kidney and liver transplant such as

Tacrolimus Tacrolimus, sold under the brand name Prograf among others, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also ...

(marketed as PanGraf),

Mycophenolic acid Mycophenolic acid (MPA) is an immunosuppressant medication used to prevent rejection following organ transplantation and to treat autoimmune conditions such as Crohn's disease and lupus. Specifically it is used following kidney, heart, and live ...

(Mycept), mycophenolate sodium (Mycept S), etc. It also markets generic forms of Tacrolimus in the

United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

, among many other developing countries.

Nephrology

Panacea Biotec has a focused presence in nephrology therapy in the highly specialized organ transplantation and dialysis management segments. It offers a range of pre-transplant and post-transplant therapies that include drugs such as

lanthanum carbonate Lanthanum carbonate, La( C O3)3, is the salt formed by lanthanum(III) cations and carbonate anions. It is an ore of lanthanum metal (bastnäsite), along with monazite. Chemistry Lanthanum carbonate is used as a starting material in lanthanum c ...

sevelamer Sevelamer (rINN) is a phosphate binding medication used to treat hyperphosphatemia in patients with chronic kidney disease. When taken with meals, it binds to dietary phosphate and prevents its absorption. Sevelamer was invented and developed by ...

, and

valganciclovir Valganciclovir, sold under the brand name Valcyte among others, is an antiviral medication used to treat cytomegalovirus (CMV) infection in those with HIV/AIDS or following organ transplant. It is often used long term as it only suppresses rath ...

in conventional and novel

drug delivery Drug delivery refers to approaches, formulations, manufacturing techniques, storage systems, and technologies involved in transporting a pharmaceutical compound to its target site to achieve a desired therapeutic effect. Principles related to d ...

systems.

Gastroenterology and orthopaedic

Panacea Biotec has many products for treatment of

arthritis Arthritis is a term often used to mean any disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints. In som ...

haemorrhoids Hemorrhoids (or haemorrhoids), also known as piles, are vascular structures in the anal canal. In their normal state, they are cushions that help with stool control. They become a disease when swollen or inflamed; the unqualified term ''hemo ...

, acid reflux, and other gastrointestinal problems. Its most prominent product is Sitcom, a euphorbia prostata extract that helps different grades of

. It also markets a once-a-day combination of regular and controlled-release

Aceclofenac Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It was patented in 1983 and approved for ...

(generic to Clanza CR) under the brand name Willgo CR.

Oncology

Panacea Biotec has many brands marketed in India for the 'affordable' treatment for cancer, viz,

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...

brain tumor A brain tumor occurs when abnormal cells form within the brain. There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. These can be further classified as primary tumors, which start within the brain, and seconda ...

, ovarian cancer,

pancreatic cancer Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of t ...

, prostate cancer and colorectal cancer. One of its most prominent brand in this segment is, PacliAll, which is a generic version of Abraxane Protein-bound paclitaxel. The company has plans to market the product in the US as per the patent settlement.

Diabetes

The company has extensively focused on its diabetic portfolio with formulations such as

gliclazide Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth. ...

metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. ...

, and

glimepiride Glimepiride, is an anti-diabetic medication used to treat type 2 diabetes. It is less preferred than metformin. Use is recommended together with diet and exercise. It is taken by mouth. Glimepiride takes up to three hours for maximum effect and l ...

that are marketed in India and other developing markets under the brand names Glizid, Glizid M, Glizid MR, Betaglim, and Metlong. It is one of the largest diabetic companies in its represented market.

Vaccines

Panacea Biotec markets many generic and novel vaccines in India and many global markets. Some of its vaccines are Pre-qualified by the

WHO Who or WHO may refer to: * Who (pronoun), an interrogative or relative pronoun * Who?, one of the Five Ws in journalism * World Health Organization Arts and entertainment Fictional characters * Who, a creature in the Dr. Seuss book ''Horton Hear ...

. ''The listing below is for named vaccines; Panacea Biotec produces many vaccines which do not bear trade names.'' *

Polio vaccine Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used: an inactivated poliovirus given by injection (IPV) and a weakened poliovirus given by mouth (OPV). The World Health Organization (WHO) recommends all chil ...

s * Haemophilus influenzae type b vaccines * Diphtheria, tetanus and polio combined vaccines * DPT, haemophilus combined vaccines * DPT, polio combined vaccines * DPT, haemophilus, polio combined vaccines * DPT, haemophilus, polio, hepatitis B combined vaccines *

Dengue vaccine Dengue vaccine is a vaccine used to prevent dengue fever in humans. Development of dengue vaccines began in the 1920s, but was hindered by the need to create immunity against all four dengue serotypes. As of 2022, there are two commercially ava ...

s *

Influenza vaccine Influenza vaccines, also known as flu shots, are vaccines that protect against infection by influenza viruses. New versions of the vaccines are developed twice a year, as the influenza virus rapidly changes. While their effectiveness varies fr ...

s *

Tetanus vaccine Tetanus vaccine, also known as tetanus toxoid (TT), is a toxoid vaccine used to prevent tetanus. During childhood, five doses are recommended, with a sixth given during adolescence. After three doses, almost everyone is initially immune, but a ...

s *

Pneumococcal vaccine Pneumococcal vaccines are vaccines against the bacterium ''Streptococcus pneumoniae''. Their use can prevent some cases of pneumonia, meningitis, and sepsis. There are two types of pneumococcal vaccines: conjugate vaccines and polysaccharide va ...

Notable achievements

* In 1998, Panacea Biotec was awarded its first product patent fo
Nimulid transgel
*In 2005, Panacea Biotec was the first to launch a fully-liquid

Pentavalent vaccine A pentavalent vaccine, also known as a 5-in-1 vaccine, is a combination vaccine with five individual vaccines conjugated into one. Pentavalent vaccine frequently refers to the 5-in-1 vaccine protecting against diphtheria, tetanus, whooping cough, ...

(DTwP-HepB-Hib), EasyFive in India and it was subsequently, pre-qualified by the

for introduction in various countries designated by the

GAVI GAVI, officially Gavi, the Vaccine Alliance (previously the GAVI Alliance, and before that the Global Alliance for Vaccines and Immunization) is a public–private global health partnership with the goal of increasing access to immunization ...

vaccination alliance. *In 2006, collaboration with the Netherlands Vaccine Institute (the Nederlands Vaccin Instituut (NVI)) for manufacture and marketing of a finished inactivated polio Vaccine (IPV) and a number of IPV-based combination vaccines in India and across the globe *In 2008,

prequalification for fully liquid innovative combination

pentavalent vaccine A pentavalent vaccine, also known as a 5-in-1 vaccine, is a combination vaccine with five individual vaccines conjugated into one. Pentavalent vaccine frequently refers to the 5-in-1 vaccine protecting against diphtheria, tetanus, whooping cough, ...

, EasyFive against five deadly infectious diseases (DTwP+ Hep B+ Hib) of early childhood * In 2011, Panacea Biotec was the first to launch PacliAll, the world's first generic to Abraxane Protein-bound paclitaxel in India. * In 2017, Panacea Biotec was the first to launch a fully-liquid Hexavalent vaccine (DTwP-HepB-Hib-IPV), EasySix in India.

Hospital venture

Panacea Biotec sold its near-completed hospital in

Delhi Delhi, officially the National Capital Territory (NCT) of Delhi, is a city and a union territory of India containing New Delhi, the capital of India. Straddling the Yamuna river, primarily its western or right bank, Delhi shares borders w ...

NCR to

Narayana Hrudayalaya Narayana Health (formerly known as Narayana Hrudyalaya) is an Indian chain of multi-speciality hospitals, heart centres, and primary care facilities with its headquarters in Bengaluru, India. It was founded by Dr. Devi Shetty in the year 2000 ...

in April 2017 for 180 crores; effectively, exiting the hospital business.

References

External links

Panacea Biotec's official site
{{Authority control Pharmaceutical companies of India Biotechnology companies of India Vaccine producers Generic drug manufacturers Manufacturing companies based in Delhi Pharmaceutical companies established in 1984 COVID-19 vaccine producers