The phosphotransferases system (PTS-GFL) superfamily is a

superfamily SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, str ...

of phosphotransferase enzymes that facilitate the transport of glucose, glucitol (G),

fructose Fructose, or fruit sugar, is a Ketose, ketonic monosaccharide, simple sugar found in many plants, where it is often bonded to glucose to form the disaccharide sucrose. It is one of the three dietary monosaccharides, along with glucose and galacto ...

(F) and

lactose Lactose is a disaccharide sugar synthesized by galactose and glucose subunits and has the molecular formula C12H22O11. Lactose makes up around 2–8% of milk (by mass). The name comes from ' (gen. '), the Latin word for milk, plus the suffix '' - ...

(L). Classification has been established through phylogenic analysis and bioinformatics. The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC). The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies. The four families that make up the PTS-GFL superfamily include:
4.A.1
– The PTS Glucose-Glucoside (Glc) Family
4.A.2
– The PTS Fructose-Mannitol (Fru) Family
4.A.3
– The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family
4.A.4
– The PTS Glucitol (Gut) Family

References

{{reflist Membrane proteins Transmembrane proteins Transmembrane transporters Transport proteins Integral membrane proteins Protein superfamilies

See also

Further reading

References