Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an
enzyme that in humans is encoded by the ''PPP2R2B''
gene.
The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major
Ser/
Thr phosphatases, and it is implicated in the negative control of
cell growth
Cell growth refers to an increase in the total mass of a cell, including both cytoplasmic, nuclear and organelle volume. Cell growth occurs when the overall rate of cellular biosynthesis (production of biomolecules or anabolism) is greater than ...
and
division. It consists of a common
heteromeric core enzyme, which is composed of a
catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate
substrate
Substrate may refer to:
Physical layers
*Substrate (biology), the natural environment in which an organism lives, or the surface or medium on which an organism grows or is attached
** Substrate (locomotion), the surface over which an organism lo ...
selectivity and catalytic activity. This gene encodes a beta
isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of
autosomal dominant
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome. The first variant is termed dominant and t ...
spinocerebellar ataxia 12.
References
Further reading
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External links
GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 12
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