PL-6983 is a synthetic

peptide Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides. A ...

and selective MC₄ receptor

agonist An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...

which is under development by

Palatin Technologies Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or ...

for the treatment of

female sexual dysfunction Female sexual arousal disorder (FSAD) is a disorder characterized by a persistent or recurrent inability to attain sexual arousal or to maintain arousal until the completion of a sexual activity. The diagnosis can also refer to an inadequate l ...

and

erectile dysfunction Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men.Cunningham GR, Rosen RC. Overview of male ...

. It was developed as a successor to/replacement of

bremelanotide Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or ...

(PT-141) due to concerns of the

side effect In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequence ...

of increased

blood pressure Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...

seen with the latter in

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

s. Relative to bremelanotide, PL-6983 produces significantly lower increases in blood pressure in

animal model An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of ha ...

s. The drug has reportedly been in

pre-clinical development In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug ...

for all medical indications since 2008. Palatin has stated that "We are focusing development efforts on bremelanotide for emale sexual dysfunction but are continuing evaluation of PL-6983." The

chemical structure A chemical structure determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid. Molecular geometry refers to the spatial arrangement of at ...

of PL-6983 has yet to be made public.

References

External links

PL-6983 for Sexual Dysfunction - Palatin TechnologiesPL-6983 for Female Sexual Dysfunction - Palatin TechnologiesPalatin Obtains $21.1M to Advance Programs in Female Sexual Dysfunction and Asthma - Genetic Engineering and Biotechnology NewsResearch Programme: Sexual Dysfunction Therapy (PL-6983) - Palatin Technologies - AdisInsightHow Sildenax Works? Composition & Benefits of Sildenax - Nutri MediHow Medicines Work To Improve Potency - Vera Farmacia
Aphrodisiacs Drugs with undisclosed chemical structures Erectile dysfunction drugs Female sexual dysfunction drugs Melanocortin receptor agonists Peptides {{Nervous-system-drug-stub

See also

References

External links