Membrane-associated phosphatidylinositol transfer protein 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''PITPNM1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.
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It was found that aggressive
metastasized cancer cells produced more of the PITPNC1 protein. In contrast,
tumor cells
A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tissue, and persists ...
that had not spread had lower expression of PITPNC1. Studies reveal that PITPNC1 promotes
malignant
Malignancy () is the tendency of a medical condition to become progressively worse.
Malignancy is most familiar as a characterization of cancer. A ''malignant'' tumor contrasts with a non-cancerous ''benign'' tumor in that a malignancy is not s ...
secretion by binding
Golgi-resident
PI4P and localizing
RAB1B
Ras-related protein Rab-1B is a protein that in humans is encoded by the ''RAB1B'' gene.
Interactions
RAB1B has been shown to Protein-protein interaction, interact with GOLGA2.
References
Further reading
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to the Golgi. RAB1B localization to the Golgi allows for the recruitment of
GOLPH3 (Golgi phosphoprotein 3), which facilitates Golgi extension and enhanced
vesicular release. PITPNC1-mediated vesicular release drives metastasis by increasing the secretion of pro-invasive and pro-angiogenic mediators
HTRA1,
MMP1
Interstitial collagenase, also known as fibroblast collagenase, and matrix metalloproteinase-1 (MMP-1) is an enzyme that in humans is encoded by the ''MMP1'' gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. ...
,
FAM3C,
PDGFA
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the ''PDGFA'' gene.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors ...
, and
ADAM10
A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ''ADAM10'' gene.
Function
Members of the ADAM family are cell surface proteins with a uni ...
.
Interactions
PITPNM1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
PTK2B
Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the ''PTK2B'' gene.
Function
This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced regulation of ion channels and activation of the ...
.
References
Further reading
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