PF-05105679 is a drug which acts as a potent and selective blocker of the

TRPM8 Transient receptor potential cation channel subfamily M (melastatin) member 8 (TRPM8), also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the ''TRPM8'' gene. The TRPM8 channel is the primary molecular ...

ion channel, which is the main receptor responsible for the sensation of

cold Cold is the presence of low temperature, especially in the atmosphere. In common usage, cold is often a subjective perception. A lower bound to temperature is absolute zero, defined as 0.00K on the Kelvin scale, an absolute thermodynamic ...

. It was developed as a potential analgesic, and blocks the sensation of cold in both animals and human trials. It also lowers

core body temperature Normal human body-temperature (normothermia, euthermia) is the typical temperature range found in humans. The normal human body temperature range is typically stated as . Human body temperature varies. It depends on sex, age, time of day, exert ...

in small mammals, but does not produce this effect in humans in the normal dosage range.

References

Quinolines Tertiary amines Benzoic acids Fluoroarenes Amides {{pharm-stub

See also

References