PF-00446687 is a drug developed by
Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
for the treatment of
erectile dysfunction, which is a non-peptide
agonist selective for the
melanocortin receptor
Melanocortin receptors are members of the rhodopsin family of 7-transmembrane G protein-coupled receptors.
There are five known members of the melanocortin receptor system each with differing specificities for melanocortins:
* . MC1R is associat ...
subtype
MC4. It was found to be active in preliminary
human trials, with the 200mg dose being of similar effectiveness to 100mg
sildenafil, though lower doses were ineffective.
While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC
4 subtype can produce similar
aphrodisiac
An aphrodisiac is a substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior. Substances range from a variety of plants, spices, foods, and synthetic chemicals. Natural aphrodisiacs like cannabis or cocai ...
effects to older non-selective peptide-based melanocortin receptor agonists like
melanotan II and
bremelanotide
Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or ...
, without the side effects caused by action at the other melanocortin receptor subtypes.
See also
*
PL-6983
*
PF-219,061
PF-219,061 is a drug that was under development by Pfizer which acts as a potent and highly selective agonist for the dopamine D3 receptor. It was under development as a potential medication for the treatment of female sexual dysfunction. I ...
*
UK-414,495
References
External links
Viagra, Cialis & Kamagra
Erectile dysfunction drugs
Female sexual dysfunction drugs
Melanocortin receptor agonists
4-Phenylpiperidines
Pfizer brands
Tert-butyl compounds
Fluoroarenes
Experimental drugs
Aphrodisiacs
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