PF-00446687 is a drug developed by

Pfizer Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...

for the treatment of erectile dysfunction, which is a non-peptide agonist selective for the

melanocortin receptor Melanocortin receptors are members of the rhodopsin family of 7-transmembrane G protein-coupled receptors. There are five known members of the melanocortin receptor system each with differing specificities for melanocortins: * . MC1R is associat ...

subtype MC₄. It was found to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective. While it is unclear whether PF-00446687 itself will be potent and effective enough to be developed for medical use, it has demonstrated that selectively targeting the MC₄ subtype can produce similar

aphrodisiac An aphrodisiac is a substance that increases sexual desire, sexual attraction, sexual pleasure, or sexual behavior. Substances range from a variety of plants, spices, foods, and synthetic chemicals. Natural aphrodisiacs like cannabis or cocai ...

effects to older non-selective peptide-based melanocortin receptor agonists like melanotan II and

bremelanotide Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women. Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or ...

, without the side effects caused by action at the other melanocortin receptor subtypes.

References

External links

Viagra, Cialis & Kamagra
Erectile dysfunction drugs Female sexual dysfunction drugs Melanocortin receptor agonists 4-Phenylpiperidines Pfizer brands Tert-butyl compounds Fluoroarenes Experimental drugs Aphrodisiacs {{genito-urinary-drug-stub

See also

References

External links