PDE7B is a mammalian gene that encodes a 3'5'-

cyclic nucleotide phosphodiesterase 3′,5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate to a nucleoside 5′-phosphate: :nucleoside 3′,5′-cyclic phosphate + ...

(PDE) that converts 3'5'-cyclic adenosine monophosphate (

cAMP Camp may refer to: Outdoor accommodation and recreation * Campsite or campground, a recreational outdoor sleeping and eating site * a temporary settlement for nomads * Camp, a term used in New England, Northern Ontario and New Brunswick to descri ...

) to 5'AMP as part of cyclic nucleotide signaling pathways.Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583. There are 21 PDE genes in mammals that are pharmacologically-grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for

relative to cGMP.

References

{{Reflist Enzymes Molecular biology