PB-22 (QUPIC, SGT-21 or 1-pentyl-1''H''-indole-3-carboxylic acid 8-quinolinyl ester) is a
designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in
synthetic cannabis
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthetic ...
products in Japan in 2013. PB-22 represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of
JWH-018 and its
analogs, or the amide of
APICA APICA or Apica may refer to:
Toponyms
* Apica River, stream in Charlevoix Regional County Municipality, Capitale-Nationale, Quebec, Canada
* Mont-Apica, Quebec, unorganized territory in Lac-Saint-Jean-Est Regional County Municipality, Saguenayâ ...
and its analogs.
PB-22 has an
EC50 of 5.1 nM for human CB
1 receptors, and 37 nM for human CB
2 receptors.
PB-22 produces
bradycardia
Bradycardia (also sinus bradycardia) is a slow resting heart rate, commonly under 60 beats per minute (BPM) as determined by an electrocardiogram. It is considered to be a normal heart rate during sleep, in young and healthy or elderly adults, a ...
and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity.
The magnitude and duration of hypothermia induced in rats by PB-22 was notably greater than
JWH-018,
AM-2201,
UR-144
UR-144 (TMCP-018, KM-X1, MN-001, YX-17) is a drug invented by Abbott Laboratories, that acts as a selective full agonist of the peripheral cannabinoid receptor CB2, but with much lower affinity for the psychoactive CB1 receptor.
Pharmacology
U ...
,
XLR-11
XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related t ...
,
APICA APICA or Apica may refer to:
Toponyms
* Apica River, stream in Charlevoix Regional County Municipality, Capitale-Nationale, Quebec, Canada
* Mont-Apica, Quebec, unorganized territory in Lac-Saint-Jean-Est Regional County Municipality, Saguenayâ ...
, or
STS-135, with a reduction of body temperature still observable six hours after dosing.
One clinical toxicology study found PB-22 to be the cause of seizures in a human and his dog.
History
PB-22 was originally developed by New Zealand legal highs company
Stargate International in 2012 as SGT-21, intended to be a structural hybrid of
QMPSB and
JWH-018. However, no intellectual property protection was applied for and the compound quickly became subject to widespread grey-market sales outside the control of the inventors.
Detection
A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
Legal status
As of 9 May 2014, PB-22 is no longer legal in New Zealand.
In January 2014, PB-22 was designated as a
Schedule I controlled substance in the United States.
In
Ohio
Ohio () is a state in the Midwestern region of the United States. Of the fifty U.S. states, it is the 34th-largest by area, and with a population of nearly 11.8 million, is the seventh-most populous and tenth-most densely populated. The sta ...
, PB-22 is illegal.
Florida also has banned PB-22.
Since 13 December 2014 it is also illegal in Germany because of adding the substance to the BtMG
Anlage II.
As of October 2015 PB-22 is a controlled substance in China.
See also
*
5F-PB-22
5F-PB-22 (5F-QUPIC or quinolin-8-yl 1-pentyfluoro-1''H''-indole-3-8-carboxylate) is a designer drug which acts as a cannabinoid agonist. The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relati ...
*
QUCHIC
*
APICA APICA or Apica may refer to:
Toponyms
* Apica River, stream in Charlevoix Regional County Municipality, Capitale-Nationale, Quebec, Canada
* Mont-Apica, Quebec, unorganized territory in Lac-Saint-Jean-Est Regional County Municipality, Saguenayâ ...
References
{{Cannabinoids
Cannabinoids
Designer drugs
Indoles