Oskar Piloty (30 April 1866 – 6 October 1915) was a German chemist.

Life

Oskar Piloty was born the son of the painter

Karl von Piloty Karl Theodor von Piloty (1 October 1826 – 21 July 1886) was a German painter, noted for his historical subjects, and recognised as the foremost representative of the realistic school in Germany. Life and work Piloty was born in Munich. His fat ...

Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by popu ...

. Due to the closeness of the Piloty family to the chemist

Ludwig Knorr Ludwig Knorr (2 December 1859 – 4 June 1921) was a German chemist. Together with Carl Paal, he discovered the Paal–Knorr synthesis, and the Knorr quinoline synthesis and Knorr pyrrole synthesis are also named after him. The synthesis in 18 ...

, who later married the sister of Oskar Piloty, he started studying chemistry at

Adolf von Baeyer Johann Friedrich Wilhelm Adolf von Baeyer (; 31 October 1835 – 20 August 1917) was a German chemist who synthesised indigo and developed a nomenclature for cyclic compounds (that was subsequently extended and adopted as part of the IUPAC org ...

's laboratory at the

University of Munich The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's List of universities in Germany, sixth-oldest u ...

in 1888. After failing an exam by Bayer in 1889 he transferred to the

University of Würzburg The Julius Maximilian University of Würzburg (also referred to as the University of Würzburg, in German ''Julius-Maximilians-Universität Würzburg'') is a public research university in Würzburg, Germany. The University of Würzburg is one of ...

. He and his colleagues speculated that he failed because he fell in love with the daughter of Baeyer; Piloty married her in 1892. At the

he worked with

Emil Fischer Hermann Emil Louis Fischer (; 9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of dra ...

on the chemistry of

sugar Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include glucose, fructose, and galactose. Compound sugars, also called disaccharides or double ...

s, receiving his PhD in 1890. In 1891, they published the preparation of a novel unnatural sugar, -

ribose Ribose is a simple sugar and carbohydrate with molecular formula C5H10O5 and the linear-form composition H−(C=O)−(CHOH)4−H. The naturally-occurring form, , is a component of the ribonucleotides from which RNA is built, and so this compo ...

, by the

epimerisation In stereochemistry, an epimer is one of a pair of diastereomers. The two epimers have opposite absolute configuration, configuration at only one stereogenic center out of at least two. All other stereogenic centers in the molecules are the same in ...

of -arabonic acid and reduction of the resulting

lactone Lactones are cyclic carboxylic esters, containing a 1-oxacycloalkan-2-one structure (), or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. Lactones are formed by intramolecular esterification of the co ...

. It was not until work by

Phoebus Levene Phoebus Aaron Theodore Levene (25 February 1869 – 6 September 1940) was a Russian born American biochemist who studied the structure and function of nucleic acids. He characterized the different forms of nucleic acid, DNA from RNA, and fo ...

and

Walter Jacobs Marion Walter Jacobs (May 1, 1930 – February 15, 1968), known as Little Walter, was an American blues musician, singer, and songwriter, whose revolutionary approach to the harmonica had a strong impact on succeeding generations, earning him ...

in 1909 that it was recognised that -ribose is a

natural product A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical syn ...

, the

enantiomer In chemistry, an enantiomer ( /ɪˈnænti.əmər, ɛ-, -oʊ-/ ''ih-NAN-tee-ə-mər''; from Ancient Greek ἐνάντιος ''(enántios)'' 'opposite', and μέρος ''(méros)'' 'part') – also called optical isomer, antipode, or optical ant ...

of Fischer and Piloty's product, and an essential component of

nucleic acid Nucleic acids are biopolymers, macromolecules, essential to all known forms of life. They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous base. The two main cl ...

s. In 1892, he followed Fischer to the

University of Berlin Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative o ...

where he worked until his father-in-law offered him a position at the University of Munich in 1900. He accepted the position despite having a better offer from Fischer. He worked on the structure of natural products such as

hemoglobin Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocyte ...

Piloty's acid Piloty's acid is an organic compound with the formula C6H5SO2N(H)OH. A white solid, it is the benzenesulfonyl derivative of hydroxylamine. It is one of the main reagents used to generate nitroxyl (HNO), a highly reactive species that is implicate ...

is named after him. Although he was too old to be drafted for

World War I World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

, he fought at the Western Front where he was killed during a fight at the

Second Battle of Champagne The Second Battle of Champagne ( or Autumn Battle) in World War I was a French offensive against the German army at Champagne that coincided with an Anglo-French assault at north-east Artois and ended with French retreat. Battle On 25 Septem ...

in 1915 near Sommepy.

References

1866 births 1915 deaths 20th-century German chemists Scientists from Munich Ludwig Maximilian University of Munich alumni University of Würzburg alumni Humboldt University of Berlin faculty Ludwig Maximilian University of Munich faculty German military personnel killed in World War I People from the Kingdom of Bavaria Military personnel of Bavaria 19th-century German chemists {{Germany-chemist-stub