59 kDa 2'-5'-oligoadenylate synthetase-like protein is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''OASL''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
is a protein family of structurally similar proteins, including
OAS1
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the ''OAS1'' gene.
This gene encodes a member of the 2-5A synthetase family, which include essential proteins involved in the innate immune response to viral infection.
...
,
OAS2
2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the ''OAS2'' gene.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded pr ...
, and
OAS3
2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the ''OAS3'' gene.
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' o ...
. OASL, like the proteins of 2'-5'-oligoadenylate synthase family, is induced by
interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten the ...
s.
See also
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Oasl2, a mouse gene, which is a
paralog
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spec ...
of mouse gene Oasl1, the
ortholog
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spec ...
of this gene
References
Further reading
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