''Ozzy & Drix'' is an American animated television series based on the 2001 film ''

Osmosis Jones ''Osmosis Jones'' is a 2001 American live-action/animated buddy cop crime action comedy film written by Marc Hyman. Combining live-action sequences directed by the Farrelly brothers and animation directed by Piet Kroon and Tom Sito, the film sta ...

''. It serves as a spiritual successor to the film. It centers on Osmosis "Ozzy" Jones, a cheeky-chappy

white blood cell White blood cells, also called leukocytes or leucocytes, are the cell (biology), cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and de ...

, and Drix, a level-headed cold pill, who battle germs and viruses inside the body of teenage boy Hector Cruz. The series is set in a stylized version of the

human body The human body is the structure of a Human, human being. It is composed of many different types of Cell (biology), cells that together create Tissue (biology), tissues and subsequently organ systems. They ensure homeostasis and the life, viabi ...

, which resembles a city where

microorganisms A microorganism, or microbe,, ''mikros'', "small") and ''organism'' from the el, ὀργανισμός, ''organismós'', "organism"). It is usually written as a single word but is sometimes hyphenated (''micro-organism''), especially in olde ...

and cells are anthropomorphic. Produced by Conundrum Entertainment and Warner Bros. Animation, the series aired on Kids' WB for two seasons and 26 episodes from 2002 to 2004. It also aired on

Cartoon Network Cartoon Network (often abbreviated as CN) is an American cable television channel owned by Warner Bros. Discovery. It is a part of The Cartoon Network, Inc., a division that also has the broadcasting and production activities of Boomerang, Car ...

from 2004 to 2006.

Premise

At the beginning of the series, Osmosis "Ozzy" Jones ( Phil LaMarr), a

with an impulsive personality and a penchant for challenging authority, and Drix (

Jeff Bennett Jeffrey Glenn Bennett (born October 2, 1962) is an American voice actor who voiced Johnny Bravo in the Johnny Bravo, eponymous television series, Dexter's Dad in ''Dexter's Laboratory'', Brooklyn in ''Gargoyles (TV series), Gargoyles'' and List o ...

), a straight-laced and by-the-books cold pill, pursue a

scarlet fever Scarlet fever, also known as Scarlatina, is an infectious disease caused by ''Streptococcus pyogenes'' a Group A streptococcus (GAS). The infection is a type of Group A streptococcal infection (Group A strep). It most commonly affects childr ...

bacterium ( Tim Curry). During the chase, the three get sucked up by a mosquito from their host body Frank DeTorre (Jeff Bennett) (who has recently resumed his poor eating habits) (it is possible that this is a different version of the series as opposed to the movie) and are transported to the body of a teenage boy named Hector Cruz (Justin Cowden). After defeating the virus and settling into their new home, Ozzy and Drix are hired as

private investigator A private investigator (often abbreviated to PI and informally called a private eye), a private detective, or inquiry agent is a person who can be hired by individuals or groups to undertake investigatory law services. Private investigators of ...

s, vowing to protect Hector's health and guide him through the misadventures of adolescence. Supporting characters include Maria Amino ( Tasia Valenza), a white blood cell cop who is highly skilled at fighting and also becomes a love interest for Drix; Mayor Paul Spryman ( Alanna Ubach), the immature teenage mayor of the city of Hector; Chief Gluteus (

Jim Cummings James Jonah Cummings (born November 3, 1952) is an American voice actor. Since beginning his career in the 1980s, he has appeared in almost 400 roles. Cummings has frequently worked with The Walt Disney Company and Warner Bros., including as th ...

), a stern muscle cell who serves as the city's police chief and Maria's superior; Ellen Patella ( Vivica A. Fox), an attorney-at-law who helps cells find homes in Hector, and who becomes Ozzy's new love interest to replace Leah Estrogen after forever leaving her and Frank; and the Brain Cell Advisors (

Pat Fraley Patrick Howard Fraley (born February 18, 1949) is an American voice actor and voice-over teacher, known as the voice of Krang, Casey Jones, Baxter Stockman and numerous other characters in the 1987 ''Teenage Mutant Ninja Turtles'' animated tele ...

), advisors who help Mayor Spryman run the city due to Spryman being incompetent in his job. Recurring characters include The Mole ( Jeffrey Tambor), a former secret agent who holds information on what is happening within Hector; Dander (

Frank Welker Franklin Wendell Welker (born March 12, 1946) is an American voice actor. He began his career in the 1960s, and holds over 860 film, television, and video game credits as of 2022, making him one of the most prolific voice actors of all time. With ...

), Drix's pet dog germ formed from the saliva of Hector's dog Uno; Christine Kolchuck ( Kimberly Brooks), a friendly student who Hector has a crush on and looks out for Hector; Travis Lum (

Rob Paulsen Robert Frederick Paulsen III (born March 11, 1956) is an American voice actor, known for his roles in numerous animated television series and films. He received a Daytime Emmy Award for Outstanding Performer in an Animated Program and three Anni ...

), Hector's classmate and best friend who also looks out for him; Ernst Strepfinger ( Brad Garrett in season 1, Cummings in season 2), a villainous germ who uses a gang of germs and

virus A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Since Dmitri Ivanovsky's 1 ...

es to carry out his dirty work; Uno (Frank Welker), Hector's dog whom he adopted in "Oh, My Dog"; and Hector's supportive parents, Mr. and Mrs. Cruz (Alanna Ubach and Joe Lala), who look after Hector's well-being. Unlike the original film it was spun-off from, ''Ozzy & Drix'' was entirely animated and contained no live-action scenes. The series was also less intense and contained no adult humor unlike the film. The voices of Ozzy and Drix were recast with LaMarr replacing

Chris Rock Christopher Julius Rock (born February 7, 1965) is an American stand-up comedian, actor, and filmmaker. Known for his work in comic film, television and stage, he has received multiple accolades, including three Grammy Awards for best come ...

as Ozzy and Bennett replacing

David Hyde Pierce David Hyde Pierce (born April 3, 1959) is an American actor and director of stage, film and television. He starred as psychiatrist Dr. Niles Crane on the NBC sitcom ''Frasier'' from 1993 to 2004, and won four Primetime Emmy Awards and a Screen ...

as Drix. In multiple episodes, producer Ron Myrick integrated stock footage from the original film such as the human body's traffic, the inside of the mouth, and the dam bursting in the runny nose. Ozzy and Drix (not counting this show's version of Frank as he only appears in the first episode and made a small cameo in the ninth episode) are only two of the characters to return. Ozzy's girlfriend Leah, along with Phlegmming, Tom Colonic, Mrs. Boyd, Frank's daughter Shane, and Bob do not appear nor mention in the series.

Episodes

Series overview

Season 1 (2002–2003)

Season 2 (2003–2004)

Home media

The complete series was released on DVD on June 20, 2017 as manufactured on demand (MOD) on DVD-R and part of the

Warner Archive Collection The Warner Archive Collection is a home video division for releasing classic and cult films from Warner Bros.' library. It started as a manufactured-on-demand (MOD) DVD series by Warner Bros. Home Entertainment on March 23, 2009, with the inte ...

References

External links

*
Ozza & Drix
at the Big Cartoon Database {{DEFAULTSORT:Ozza and Drix Episode list using the default LineColor 2000s American animated television series 2000s American comic science fiction television series 2002 American television series debuts 2004 American television series endings Kids' WB original shows American animated television spin-offs American children's animated action television series American children's animated adventure television series American children's animated comic science fiction television series American children's animated science fantasy television series American sequel television series Anime-influenced Western animated television series Human body in popular culture Osmosis Jones Animated television shows based on films Television shows set in Washington (state) Television series by Warner Bros. Animation Animated television series about robots Animated television series about families The WB original programming