Oxytocin Challenge Test
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A contraction stress test (CST) is performed near the end of
pregnancy Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ca ...
(34 weeks' gestation) to determine how well the
fetus A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal deve ...
will cope with the contractions of
childbirth Childbirth, also known as labour and delivery, is the ending of pregnancy where one or more babies exits the internal environment of the mother via vaginal delivery or caesarean section. In 2019, there were about 140.11 million births globall ...
. The aim is to induce contractions and monitor the
fetus A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal deve ...
to check for
heart rate Heart rate (or pulse rate) is the frequency of the heartbeat measured by the number of contractions (beats) of the heart per minute (bpm). The heart rate can vary according to the body's physical needs, including the need to absorb oxygen and excr ...
abnormalities using a
cardiotocograph Cardiotocography (CTG) is a technique used to monitor the fetal heartbeat and the uterine contractions during pregnancy and labour. The machine used to perform the monitoring is called a cardiotocograph. Fetal heart sounds was described as early ...
. A CST is one type of antenatal fetal surveillance technique. During uterine contractions, fetal oxygenation is worsened. Late decelerations in
fetal heart rate A fetus or foetus (; plural fetuses, feti, foetuses, or foeti) is the unborn offspring that develops from an animal embryo. Following embryonic development the fetal stage of development takes place. In human prenatal development, fetal dev ...
occurring during uterine contractions are associated with increased fetal death rate,
growth retardation Delayed milestone, also called developmental delays, is used to describe the condition where a child does not reach one of these stages at the expected age. However, in most cases, a wide variety of ages can be considered normal, and not a cause fo ...
and neonatal depression. This test assesses fetal heart rate in response to uterine contractions via
electronic fetal monitoring Cardiotocography (CTG) is a technique used to monitor the fetal heartbeat and the uterine contractions during pregnancy and labour. The machine used to perform the monitoring is called a cardiotocograph. Fetal heart sounds was described as earl ...
. Uterine activity is monitored by tocodynamometer.


Medical uses

The CST is used for its high
negative predictive value The positive and negative predictive values (PPV and NPV respectively) are the proportions of positive and negative results in statistics and diagnostic tests that are true positive and true negative results, respectively. The PPV and NPV descr ...
. A negative result is highly predictive of fetal wellbeing and tolerance of labor. The test has a poor
positive predictive value The positive and negative predictive values (PPV and NPV respectively) are the proportions of positive and negative results in statistics and diagnostic tests that are true positive and true negative results, respectively. The PPV and NPV descr ...
with false-positive results in as many as 30% of cases. A positive CST indicates high risk of fetal death due to hypoxia and is a contraindication to
labor Labour or labor may refer to: * Childbirth, the delivery of a baby * Labour (human activity), or work ** Manual labour, physical work ** Wage labour, a socioeconomic relationship between a worker and an employer ** Organized labour and the labour ...
. Patient's obstetricians usually consider operative delivery in such situations.


Contraindications

This "stress test" is usually not performed if there are any signs of
premature birth Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age, as opposed to full-term delivery at approximately 40 weeks. Extreme preterm is less than 28 weeks, very early preterm birth is between 2 ...
,
placenta praevia Placenta praevia is when the placenta attaches inside the uterus but in a position near or over the cervical opening. Symptoms include vaginal bleeding in the second half of pregnancy. The bleeding is bright red and tends not to be associated wi ...
,
vasa praevia Vasa praevia is a condition in which fetal blood vessels cross or run near the internal opening of the uterus. These vessels are at risk of rupture when the supporting membranes rupture, as they are unsupported by the umbilical cord or placental ...
,
cervical incompetence Cervical weakness, also called cervical incompetence or cervical insufficiency, is a medical condition of pregnancy in which the cervix begins to dilate (widen) and efface (thin) before the pregnancy has reached term. Definitions of cervical wea ...
,
multiple gestation A multiple birth is the culmination of one multiple pregnancy, wherein the mother gives birth to two or more babies. A term most applicable to vertebrate species, multiple births occur in most kinds of mammals, with varying frequencies. Such bir ...
, previous classic
caesarian section Caesarean section, also known as C-section or caesarean delivery, is the surgical procedure by which one or more babies are delivered through an incision in the mother's abdomen, often performed because vaginal delivery would put the baby or mo ...
. Other contraindications include but are not limited to previous uterine incision with scarring, previous
myomectomy Myomectomy, sometimes also called fibroidectomy, refers to the surgical removal of uterine leiomyomas, also known as fibroids. In contrast to a hysterectomy, the uterus remains preserved and the woman retains her reproductive potential. Indica ...
entering the uterine cavity, and
PROM A promenade dance, commonly called a prom, is a dance party for high school students. It may be offered in semi-formal black tie or informal suit for boys, and evening gowns for girls. This event is typically held near the end of the school yea ...
. Any contraindication to labor is contraindication to CST.


Procedure

CST is performed weekly, as the fetus is assumed to be healthy after a negative test and should remain so for another week. This test is done in hospital or clinic setting. External fetal monitors are put in place and then either
nipple stimulation Nipple stimulation or breast stimulation is stimulation of the breast. Stimulation may be by breastfeeding, sexual activity, or an indirect non-sexual response. As part of sexual activity, the practice may be performed upon, or by, people of any ...
or IV
pitocin Synthetic oxytocin, sold under the brand name Pitocin among others, is a medication made from the peptide '' oxytocin''. As a medication, it is used to cause contraction of the uterus to start labor, increase the speed of labor, and to stop ...
(oxytocin) is used to stimulate uterine contractions.


Nipple stimulation

This is a procedure that relies on
endogenous Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell. In contrast, exogenous substances and processes are those that originate from outside of an organism. For example, es ...
release of
oxytocin Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin ...
following
nipple The nipple is a raised region of tissue on the surface of the breast from which, in females, milk leaves the breast through the lactiferous ducts to feed an infant. The milk can flow through the nipple passively or it can be ejected by smooth mu ...
stimulation, and is conducted by the patient. The
nurse Nursing is a profession within the health care sector focused on the care of individuals, families, and communities so they may attain, maintain, or recover optimal health and quality of life. Nurses may be differentiated from other health c ...
instructs the patient on the procedure, as follows. One nipple is massaged gently through clothing until a contraction begins, or for a maximum of 2 minutes. If at least 3 contractions in 10 minutes is not achieved, then the patient rests for 5 minutes and the other nipple is stimulated.American College of Obstetricians and Gynecologists (ACOG). (1999). Antepartum fetal surveillance (Practice Bulletin No. 9). Washington, DC: Author.


Oxytocin challenge test (OCT)

If adequate contractions (at least 3 in 10 minutes) cannot be achieved with nipple stimulation, an oxytocin challenge test may be performed. It involves the
intravenous Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...
administration of
exogenous In a variety of contexts, exogeny or exogeneity () is the fact of an action or object originating externally. It contrasts with endogeneity or endogeny, the fact of being influenced within a system. Economics In an economic model, an exogeno ...
oxytocin Oxytocin (Oxt or OT) is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. It plays a role in social bonding, reproduction, childbirth, and the period after childbirth. Oxytocin ...
to the pregnant woman. The target is to achieve around three contractions every ten minutes.


Interpretation


History

The CST was the first antenatal surveillance test that was developed after the development of the
cardiotocograph Cardiotocography (CTG) is a technique used to monitor the fetal heartbeat and the uterine contractions during pregnancy and labour. The machine used to perform the monitoring is called a cardiotocograph. Fetal heart sounds was described as early ...
. The oxytocin challenge test was first described in 1972 and was standardised in 1975 when the parameters of contraction number and frequency were given. Historically, a CST was done after a non reactive NST. Today, a biophysical profile (BPP) is usually performed.


See also

*
Nonstress test A nonstress test (NST) is a screening test used in pregnancy to assess fetal status by means of the fetal heart rate and its responsiveness. A cardiotocograph is used to monitor the fetal heart rate and presence or absence of uterine contractions. ...
*
Cardiotocography Cardiotocography (CTG) is a technique used to monitor the fetal heartbeat and the uterine contractions during pregnancy and labour. The machine used to perform the monitoring is called a cardiotocograph. Fetal heart sounds was described as early ...


References


External links


Contraction Stress Test
at webmd.com {{Pregnancy Tests during pregnancy