Owen McCarty is an American biomedical engineer who studies the dynamics of the vascular system in the context of cancer metastasis, cardiovascular disease, and inflammation. He is the Douglas Strain Professor and Chair of the Biomedical Engineering Department at

Oregon Health & Science University Oregon Health & Science University (OHSU) is a public research university focusing primarily on health sciences with a main campus, including two hospitals, in Portland, Oregon. The institution was founded in 1887 as the University of Oregon Medi ...

(OHSU) and a fellow of the

American Heart Association The American Heart Association (AHA) is a nonprofit organization in the United States that funds cardiovascular medical research, educates consumers on healthy living and fosters appropriate cardiac care in an effort to reduce disability and death ...

Education and career

McCarty received his B.S. in Chemical Engineering from

SUNY-Buffalo The State University of New York at Buffalo, commonly called the University at Buffalo (UB) and sometimes called SUNY Buffalo, is a public research university with campuses in Buffalo and Amherst, New York. The university was founded in 1846 ...

. He attended Johns Hopkins University to pursue his Ph.D. with Konstantinos Konstantopoulos and investigate tumor cell receptors for white blood cells and platelets. He completed his post-doctoral training under the mentorship of Steve Watson as a Wellcome Trust Fellow in the Pharmacology Department at the University of Oxford and University of Birmingham. In 2005, he accepted a faculty position in the Department of Biomedical Engineering at

. He has served as chair of the Biomedical Engineering Department since 2019 and orchestrated collaborative partnerships with OHSU's School of Medicine, School of Dentistry, and external institutions.

Current work and achievements

McCarty investigates fluid mechanics and cellular biology of the vasculature with the goal of translating these insights into molecular-targeted therapies. His research program has helped take two drug candidates to clinical trials and has also provided insight on the anti-cancer effects of aspirin.

Honors and awards

* 2002: Howard & Jacqueline Chertkof Endowed Fellowship, Johns Hopkins University * 2003: University Merit Review Award, University of Oxford * 2004 British Journal of Haematology Research Trust Award * 2004: Paper of the Year in the Platelets Section of the Journal of Thrombosis and Haemostasis * 2004: International Society on Thrombosis and Haemostasis Young Investigator Award * 2005:

Gordon Research Conference Gordon Research Conferences are a group of international scientific conferences organized by a non-profit organization of the same name. The conference topics cover frontier research in the biological, chemical, and physical sciences, and thei ...

Speaker Award * 2007: Paper of the Year in the Platelets Section of the Journal of Thrombosis and Haemostasis * 2009:

Karl Link New Investigator Award in Thrombosis * 2010:

Kenneth M. Brinkhous Young Investigator in Thrombosis Finalist * 2013:

Established Investigator Award * 2014: Fellow of the

* 2019: Best Basic Science Award at the International Sepsis Forum * 2021: Douglas Strain Endowed Professorship, OHSU Department of Biomedical Engineering

Publications

* McCarty, O. J., Mousa, S. A., Bray, P. F., & Konstantopoulos, K. (2000). Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions. ''Blood, The Journal of the American Society of Hematology'', ''96''(5), 1789-1797. *McCarty, O. J., Larson, M. K., Auger, J. M., Kalia, N., Atkinson, B. T., Pearce, A. C., ... & Watson, S. P. (2005). Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. ''Journal of biological chemistry'', ''280''(47), 39474-39484. *Cheng, Q., Tucker, E. I., Pine, M. S., Sisler, I., Matafonov, A., Sun, M. F., ... McCarty, O. J. T., ... & Gailani, D. (2010). A role for factor XIIa–mediated factor XI activation in thrombus formation in vivo. ''Blood, The Journal of the American Society of Hematology'', ''116''(19), 3981-3989. *Aslan, J. E., & McCarty, O. J. (2013). Rho GTPases in platelet function. ''Journal of Thrombosis and Haemostasis'', ''11''(1), 35-46. *Itakura, A., & McCarty, O. J. (2013). Pivotal role for the mTOR pathway in the formation of neutrophil extracellular traps via regulation of autophagy. ''American Journal of Physiology. Cell Physiology'', ''305''(3), C348-C354.

References

{{DEFAULTSORT:McCarthy, Owen Living people 21st-century American scientists Biomedical engineers Year of birth missing (living people)