Otto Emil Franz Ulrich Busse (; December 6, 1867 – February 3, 1922) was a German

pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...

. Busse was born in Gühlitz,

Prignitz Prignitz () is a ''Kreis'' (district) in the northwestern part of Brandenburg, Germany. Neighboring are (from the north clockwise) the district Ludwigslust-Parchim in Mecklenburg-Western Pomerania, the district Ostprignitz-Ruppin in Brandenburg, th ...

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

. He studied medicine at the

University of Greifswald The University of Greifswald (; german: Universität Greifswald), formerly also known as “Ernst-Moritz-Arndt University of Greifswald“, is a public research university located in Greifswald, Germany, in the state of Mecklenburg-Western Pom ...

, and subsequently became an assistant to Paul Grawitz (1850–1932), (his future father-in-law) at

Greifswald Greifswald (), officially the University and Hanseatic City of Greifswald (german: Universitäts- und Hansestadt Greifswald, Low German: ''Griepswoold'') is the fourth-largest city in the German state of Mecklenburg-Western Pomerania after Rostoc ...

. Afterwards he moved to Posen (today

Poznań Poznań () is a city on the River Warta in west-central Poland, within the Greater Poland region. The city is an important cultural and business centre, and one of Poland's most populous regions with many regional customs such as Saint John ...

, Poland), where in 1904 he became a professor of pathology. From 1911 until 1922 he was professor of

pathological anatomy Anatomical pathology (''Commonwealth'') or Anatomic pathology (''U.S.'') is a medical specialty that is concerned with the diagnosis of disease based on the macroscopic, microscopic, biochemical, immunologic and molecular examination ...

at the

University of Zurich The University of Zürich (UZH, german: Universität Zürich) is a public research university located in the city of Zürich, Switzerland. It is the largest university in Switzerland, with its 28,000 enrolled students. It was founded in 1833 f ...

, where he died. In 1894 Busse was the first to provide a written account of

cryptococcosis Cryptococcosis is a potentially fatal fungal infection of mainly the lungs, presenting as a pneumonia, and brain, where it appears as a meningitis. Cough, difficulty breathing, chest pain and fever are seen when the lungs are infected. When the ...

, caused by a yeast-like

fungus A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from th ...

now known as ''

Cryptococcus neoformans ''Cryptococcus neoformans'' is an encapsulated yeast belonging to the class Tremellomycetes and an obligate aerobe that can live in both plants and animals. Its teleomorph is a filamentous fungus, formerly referred to ''Filobasidiella neoformans' ...

''. This he discovered in a patient with chronic

periostitis Periostitis, also known as periostalgia, is a medical condition caused by inflammation of the periosteum, a layer of connective tissue that surrounds bone. The condition is generally chronic, and is marked by tenderness and swelling of the bone an ...

of the

tibia The tibia (; ), also known as the shinbone or shankbone, is the larger, stronger, and anterior (frontal) of the two bones in the leg below the knee in vertebrates (the other being the fibula, behind and to the outside of the tibia); it connects ...

. At the time he called the fungus ''Saccharomyces hominis''. During the same time period, Francesco Sanfelice cultured the yeast-like fungus from

peach The peach (''Prunus persica'') is a deciduous tree first domesticated and cultivated in Zhejiang province of Eastern China. It bears edible juicy fruits with various characteristics, most called peaches and others (the glossy-skinned, non-fu ...

juice, naming the fungus ''Saccharomyces neoformans''.The Yeasts, a Taxonomic Study
by C. P. Kurtzman, Jack W. Fell Infection caused by the fungus has also been referred to as "Busse-Buschke disease", named in conjunction with

dermatologist Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical ...

Abraham Buschke Abraham Buschke (27 September 1868 – 25 February 1943) was a Jewish German dermatologist who was a native of Nakel in the Province of Posen. Life In 1891 he received his doctorate in Berlin, and afterwards was a surgical assistant in Greifswa ...

(1868–1943).

References

NCBI
One hundred years of cryptococcosis. Medical mycology in the 19th century in Greifswald

(translated biography of Otto Busse) * ttp://www.whonamedit.com/synd.cfm/1793.html ''Busse-Buschke disease''@

Who Named It ''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliograph ...

German pathologists 1867 births 1922 deaths People from Białogard University of Greifswald alumni Academic staff of the University of Greifswald University of Zurich faculty People from the Province of Brandenburg 20th-century German physicians 20th-century German scientists {{Germany-med-bio-stub

See also

References