Ora Mendelsohn Rosen (October 26, 1935 – May 30, 1990) was an American

medical research Medical research (or biomedical research), also known as experimental medicine, encompasses a wide array of research, extending from "basic research" (also called ''bench science'' or ''bench research''), – involving fundamental scientif ...

er who investigated the influence of hormones, particularly

insulin Insulin (, from Latin ''insula'', 'island') is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the ''INS'' gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism o ...

, on the control of cell growth. She was a professor at the

Albert Einstein College of Medicine Albert Einstein College of Medicine is a research-intensive medical school located in the Morris Park neighborhood of the Bronx in New York City. Founded in 1953, Einstein operates as an independent degree-granting institution as part of t ...

and

Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in the borough of Manhattan in New York City, founded in 1884 as the New York Cancer Hospital. MSKCC is one of 52 National Cancer Institute– ...

and a member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

Early life

Rosen was born and raised on the

Upper West Side The Upper West Side (UWS) is a neighborhood in the borough of Manhattan in New York City. It is bounded by Central Park on the east, the Hudson River on the west, West 59th Street to the south, and West 110th Street to the north. The Upper West ...

Manhattan Manhattan (), known regionally as the City, is the most densely populated and geographically smallest of the five boroughs of New York City. The borough is also coextensive with New York County, one of the original counties of the U.S. state ...

. Isaac Mendelsohn, her father, was a professor of

Semitic languages The Semitic languages are a branch of the Afroasiatic language family. They are spoken by more than 330 million people across much of West Asia, the Horn of Africa, and latterly North Africa, Malta, West Africa, Chad, and in large immigra ...

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

and her mother, Fanny Soier, was a remedial reading teacher; both were

Zionist Zionism ( he, צִיּוֹנוּת ''Tsiyyonut'' after ''Zion'') is a nationalist movement that espouses the establishment of, and support for a homeland for the Jewish people centered in the area roughly corresponding to what is known in Je ...

s. Her brother was

Ezra Mendelsohn Ezra (; he, עֶזְרָא, '; fl. 480–440 BCE), also called Ezra the Scribe (, ') and Ezra the Priest in the Book of Ezra, was a Jewish scribe (''sofer'') and priest (''kohen''). In Greco-Latin Ezra is called Esdras ( grc-gre, Ἔσδρας ...

, a professor of Jewish history at the

Hebrew University of Jerusalem The Hebrew University of Jerusalem (HUJI; he, הַאוּנִיבֶרְסִיטָה הַעִבְרִית בִּירוּשָׁלַיִם) is a public research university based in Jerusalem, Israel. Co-founded by Albert Einstein and Dr. Chaim Weiz ...

. Rosen studied biology at

Barnard College Barnard College of Columbia University is a private women's liberal arts college in the borough of Manhattan in New York City. It was founded in 1889 by a group of women led by young student activist Annie Nathan Meyer, who petitioned Columbia ...

, graduating in 1956, the same year that she married the physician Samuel Rosen; they had two sons. She went on to complete a medical degree at the

Columbia University College of Physicians and Surgeons Columbia University Vagelos College of Physicians and Surgeons (VP&S) is the graduate medical school of Columbia University, located at the Columbia University Irving Medical Center in the Washington Heights neighborhood of Manhattan. Founded i ...

in 1960.

Career

After receiving her medical degree, Rosen conducted research on

biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

and

cell biology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...

New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then-Secretary of the Treasury Albert Gallatin. In 1832, the ...

. In 1966, she was hired as an assistant professor of medicine by the

. She was promoted to an associate professor a year later and made a full professor in 1975. She became chair of the college's molecular

pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...

department in 1976 and director of the

endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

division in 1977. In 1984, Rosen left the Albert Einstein College to join the faculty of

. There, she led the laboratory of developmental and membrane biology as Abby Rockefeller Mauze Chair of Experimental Therapeutics. After the death of her husband in the early 1980s, Rosen married

Jerard Hurwitz Jerard Hurwitz (November 20, 1928 – January 24, 2019) was an American biochemist who co-discovered RNA polymerase in 1960 along with Sam Weiss, Audrey Stevens, and James Bonner. He most recently worked at the Sloan-Kettering Institute in New Yo ...

, a fellow

American Cancer Society The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...

member and researcher at Memorial Sloan Kettering. Rosen's research investigated the influence of hormones, particularly

, on the control of cell growth and development. In 1985, she and a group of other scientists from Memorial Sloan Kettering and

Genentech Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within R ...

cloned the human

insulin receptor The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeo ...

(''INSR'') gene—a breakthrough in cell biology. This in turn allowed Rosen and her colleagues to study the insulin receptor's transmission of signals from outside of the cell to the inside. In recognition of her research, she was, in 1989, awarded the

Banting Medal The Banting Medal, officially the Banting Medal for Scientific Achievement, is an annual award conferred by the American Diabetes Association (ADA), which is the highest award of ADA. Inaugurated in 1941, the prize is given in memory of Sir Frederic ...

and elected to the

; she also received an award from the

American Medical Women's Association The American Medical Women's Association (AMWA) is a professional advocacy and educational organization of women in medicine, women physicians and medical students. Founded in 1915 by Bertha vanhoosen, Bertha Van Hoosen, the AMWA works to advance ...

Death

Rosen died of

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...

in Manhattan on May 30, 1990, at the age of 54.

References

{{DEFAULTSORT:Rosen, Ora Mendelsohn 1935 births 1990 deaths American medical researchers Deaths from breast cancer in New York (state) Barnard College alumni Columbia University Vagelos College of Physicians and Surgeons alumni Jewish women scientists Scientists from New York City People from the Upper West Side Albert Einstein College of Medicine faculty Jewish American scientists American women medical researchers 20th-century American women American women academics 20th-century American Jews Members of the United States National Academy of Sciences