Opigolix (, ; developmental code name ASP-1707) is a
small-molecule
Within the fields of molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs ar ...
,
non-peptide
Within the fields of molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs are ...
,
orally active gonadotropin-releasing hormone antagonist
Gonadotropin-releasing hormone antagonists (GnRH antagonists) are a class of medications that antagonize the gonadotropin-releasing hormone receptor (GnRH receptor) and thus the action of gonadotropin-releasing hormone (GnRH). They are used in ...
(GnRH antagonist) which was under development by
Astellas Pharma
is a Japanese multinational pharmaceutical company, formed on 1 April 2005 from the merger of and . On February 5, 2020, the company announced management changes effective from April 1, 2020.
Astellas is a member of the Mitsubishi UFJ Fina ...
for the treatment of
endometriosis and
rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and hands are invol ...
.
It was also under investigation for the treatment of
prostate cancer.
It reached
phase II clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, diet ...
s for both endometriosis and rheumatoid arthritis prior to the discontinuation of its development in April 2018.
See also
*
Gonadotropin-releasing hormone receptor § Antagonists
References
External links
Opigolix - AdisInsight
Abandoned drugs
Secondary alcohols
Amidines
Benzimidazoles
Fluoroarenes
GnRH antagonists
Aromatic ketones
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