Ophiorrhiza Japonica
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''Ophiorrhiza'' is a genus of flowering plants in the coffee family (
Rubiaceae The Rubiaceae are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family. It consists of terrestrial trees, shrubs, lianas, or herbs that are recognizable by simple, opposite leaves with interpetiolar stipules ...
). Species of the genus contain
camptothecin Camptothecin (CPT) is a topoisomerase inhibitor. It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of ''Camptotheca acuminata'' (Campt ...
, an
alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...
used to make
chemotherapeutic agents Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs ( chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemothera ...
.Joseph, G. and J. P. Joseph
Rediscovery of ''Ophiorrhiza caudata'' (Rubiaceae) from the Western Ghats of Kerala.
''Rheedia'' 19 45.
Viraporn, V., et al. (2010). Correlation of camptothecin-producing ability and phylogenetic relationship in the genus ''Ophiorrhiza''. ''Planta Med''. in pub. So many of Ophiorrhiza species are endemic to certain areas of western Ghats. Species include: *'' Ophiorrhiza acuminata''Sirikantaramas, S., et al. (2008)
Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants.
''PNAS'' 105:18 6782.
*'' Ophiorrhiza blumeana''Arbain, D, et al. (1998)
Unusual indole alkaloids from ''Ophiorrhiza blumeana'' Korth.
''J. Chem. Soc., Perkin Trans'' 1.
*'' Ophiorrhiza bracteata'' *'' Ophiorrhiza cantoniensis'' *'' Ophiorrhiza carinata'' *''
Ophiorrhiza caudata ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *'' Ophiorrhiza dulongensis'' *''
Ophiorrhiza filistipula ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *'' Ophiorrhiza japonica'' *''
Ophiorrhiza kuroiwai ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza liukiuensis ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza longiflora ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza lurida ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza major ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza michelloides ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza mungos ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) ...
'' *''
Ophiorrhiza nutans ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza prostrata ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza pumila ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *''
Ophiorrhiza rosea ''Ophiorrhiza'' is a genus of flowering plants in the coffee family (Rubiaceae). Species of the genus contain camptothecin, an alkaloid used to make chemotherapeutic agents.Joseph, G. and J. P. JosephRediscovery of ''Ophiorrhiza caudata'' (Rubiac ...
'' *'' Ophiorrhiza rugosa'' *'' Ophiorrhiza succirubra'' *'' Ophiorrhiza meenachilarensis''


References


External links


Vascular Plants of Gaoligong Shan, Yunnan, China: ''Ophiorrhiza''
*Darwin, S. P. (1976)
The Pacific species of ''Ophiorrhiza'' (Rubiaceae).
''Lyonia'' 1:2. Rubiaceae genera Ophiorrhizeae {{Rubioideae-stub