science Science is a systematic endeavor that Scientific method, builds and organizes knowledge in the form of Testability, testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earli ...

and mathematics, an open problem or an open question is a known problem which can be accurately stated, and which is assumed to have an objective and verifiable solution, but which has not yet been solved (i.e., no solution for it is known). In the history of science, some of these supposed open problems were "solved" by means of showing that they were not well-defined. In mathematics, many open problems are concerned with the question of whether a certain definition is or is not consistent. Two notable examples in mathematics that have been solved and ''closed'' by researchers in the late twentieth century are

Fermat's Last Theorem In number theory, Fermat's Last Theorem (sometimes called Fermat's conjecture, especially in older texts) states that no three positive integers , , and satisfy the equation for any integer value of greater than 2. The cases and have been ...

and the

four-color theorem In mathematics, the four color theorem, or the four color map theorem, states that no more than four colors are required to color the regions of any map so that no two adjacent regions have the same color. ''Adjacent'' means that two regions sha ...

.K. Appel and W. Haken (1977), "Every planar map is four colorable. Part I. Discharging", ''Illinois J. Math'' 21: 429–490. K. Appel, W. Haken, and J. Koch (1977), "Every planar map is four colorable. Part II. Reducibility", ''Illinois J. Math'' 21: 491–567. An important open mathematics problem solved in the early 21st century is the

Poincaré conjecture In the mathematical field of geometric topology, the Poincaré conjecture (, , ) is a theorem about the characterization of the 3-sphere, which is the hypersphere that bounds the unit ball in four-dimensional space. Originally conjectured ...

. Open problems exist in all scientific fields. For example, one of the most important open problems in biochemistry is the

protein structure prediction Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its secondary and tertiary structure from primary structure. Structure prediction is different ...

problem – how to predict a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

's structure from its sequence.

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* *{{Citation , title=So much more to know , journal=Science , volume=309 , issue=5731 , pages=78–102 , date=July 2005 , pmid=15994524 , doi=10.1126/science.309.5731.78b, doi-access=free
Open Problem Garden
The collection of open problems in mathematics build on the principle of user editable ("wiki") site

See also

References

External links