Ononetin is a natural product from the deoxybenzoin group, which is found in the Russian traditional medicine plant ''

Ononis spinosa ''Ononis spinosa'' is a plant belonging to the family Fabaceae, that is commonly known as spiny restharrow or just restharrow. It is found throughout much of Europe including Britain, but seldom as far north as Scotland. Description Spiny resth ...

''. It acts as an inhibitor of the transient receptor potential ion channel

TRPM3 Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the ''TRPM3'' gene. Function The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels ...

and has

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

effects in animal studies, as well as being used for research into the role of TRPM3 in the

immune system The immune system is a network of biological processes that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to parasitic worms, as well as cancer cells and objects such as wood splinte ...

dysfunction associated with

chronic fatigue syndrome Chronic fatigue syndrome (CFS), also called myalgic encephalomyelitis (ME) or ME/CFS, is a complex, debilitating, long-term medical condition. The causes and mechanisms of the disease are not fully understood. Distinguishing core symptoms are ...

References

{{Transient receptor potential channel modulators Ion channel blockers Phenyl compounds