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The Olah reagent is a nucleophilic fluorinating agent. It consists of a mixture of 70% 
hydrogen fluoride
Hydrogen fluoride (fluorane) is an inorganic compound with the chemical formula . This colorless gas or liquid is the principal industrial source of fluorine, often as an aqueous solution called hydrofluoric acid. It is an important feedstock i ...
and 30% pyridine; alcohols react with this reagent to give alkyl fluoride
Organofluorine chemistry describes the chemistry of the organofluorines, organic compounds that contain the carbon–fluorine bond. Organofluorine compounds find diverse applications ranging from oil and water repellents to pharmaceuticals, refri ...
s:
It acts as a stabilized, less volatile form of hydrogen fluoride. It is used in the fluorination of steroids and in deprotection of peptides.Review of use in organic synthesis: G. A. Olah et al., J. Fluorine Chem. 33, 377–396 (1986). Instead of hydrogen fluoride, several other fluorinating agents can be used, such as diethylaminosulfur trifluoride
Diethylaminosulfur trifluoride (DAST) is the organosulfur compound with the formula Et2NSF3. This liquid is a fluorinating reagent used for the synthesis of organofluorine compounds. The compound is colourless; older samples assume an orange colou ...
(DAST).
See also
*Ishikawa reagent
Ishikawa's reagent is a fluorinating reagent used in organic chemistry. It is used to convert alcohols into alkyl fluorides and carboxylic acids into acyl fluorides. Aldehydes and ketones do not react with it. The reagent consists of a mixture of ...
* Organofluoride
Organofluorine chemistry describes the chemistry of the organofluorines, organic compounds that contain the carbon–fluorine bond. Organofluorine compounds find diverse applications ranging from oil and water repellents to pharmaceuticals, ref ...
References
{{Reflist Fluorinating agents