Ohio Central Railroad may refer to:
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Ohio Central Railroad System, acquired by Genesee and Wyoming in 2008
**
Ohio Central Railroad (1988), one part of the system, operating a former Wheeling and Lake Erie Railway line between Warwick and Zanesville
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Ohio Central Railroad (1879–1885), predecessor of the New York Central Railroad
*
Central Ohio Railroad (1847–1915), predecessor of the Baltimore and Ohio Railroad
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