OSI-7904 is a noncompetitive liposomal
thymidylate synthase inhibitor Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This inhibition prevents the methylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiti ...
. OSI-7904 is a
benzoquinazoline folate analog with
antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to
thymidylate synthase, resulting in inhibition of
thymine nucleotide synthesis and
DNA replication.
OSI-7904L is a
liposome-encapsulated formulation of OSI-7904. Liposome encapsulation improves the efficacy and increases the
half-life of OSI-7904.
[
Its effect on solid tumors is currently under evaluation.]
References
Experimental cancer drugs
Dicarboxylic acids
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