O-1057 is an
analgesic
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...
cannabinoid
Cannabinoids () are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. The most notable cannabinoid is the phytocannabinoid tet ...
derivative created by
Organix Inc
Organix Inc is a US fine chemicals company specialising in chemical synthesis of analytical standards and custom synthesis of finished compounds and intermediates.{{Citation needed, date=February 2020
Chemistry
Organix carries out research and de ...
.,
Newburyport
Newburyport is a coastal city in Essex County, Massachusetts, United States, northeast of Boston. The population was 18,289 at the 2020 census. A historic seaport with vibrant tourism industry, Newburyport includes part of Plum Island. The mo ...
, Massachusetts, for use in scientific research. Unlike most cannabinoids discovered to date, it is water-soluble, which gives it considerable advantages over many related cannabinoids. It has moderate affinity for both
CB1 and
CB2 receptors
Receptor may refer to:
*Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...
, with
''K''i values of 8.36 nM at CB
1 and 7.95 nM at CB
2
See also
*
AM-2232
*
O-774
O-774 is a classical cannabinoid derivative which acts as a potent agonist for the cannabinoid receptors, with a ''K''i of 0.6 nM at CB1, and very potent cannabinoid effects in animal studies.
See also
* AM-2232
* O-1057
* O-1812
O-1812 ...
*
O-1812
O-1812 is an eicosanoid derivative related to anandamide that acts as a potent and highly selective agonist for the cannabinoid receptor CB1, with a ''K''i of 3.4 nM at CB1 and 3870 nM at CB2. Unlike most related compounds, O-1812 i ...
*
O-2694
O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related dru ...
*
SP-111
THC morpholinylbutyrate (SP-111, Δ9-THC-O- -(morpholin-4-yl)butyrate'') is a synthetic derivative of tetrahydrocannabinol, developed in the 1970s. It is a prodrug which is converted into THC inside the body, and was one of the first derivatives ...
References
{{cannabinoid-stub
Cannabinoids
Benzochromenes
Carboxylate esters
4-Morpholinyl compunds
Nitriles