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Nora Volkow (born 27 March 1956) is a Mexican-American
psychiatrist A psychiatrist is a physician who specializes in psychiatry, the branch of medicine devoted to the diagnosis, prevention, study, and treatment of mental disorders. Psychiatrists are physicians and evaluate patients to determine whether their sy ...
. She is currently the director of the
National Institute on Drug Abuse The National Institute on Drug Abuse (NIDA) is a United States federal government research institute whose mission is to "advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual a ...
(NIDA), which is part of the
National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...
(NIH).


Early life and education

Born in Mexico City, Volkow is a daughter of Esteban Volkov, whose mother
Zinaida Volkova Zinaida Lvovna Volkova (née Bronstein; russian: Зинаи́да Льво́вна Во́лкова; 27 March 1901 – 5 January 1933) was a Russian Marxist. She was Leon Trotsky's first daughter by his first wife, Aleksandra Sokolovskaya, a m ...
was the eldest daughter of the Russian communist revolutionary
Leon Trotsky Lev Davidovich Bronstein. ( – 21 August 1940), better known as Leon Trotsky; uk, link= no, Лев Давидович Троцький; also transliterated ''Lyev'', ''Trotski'', ''Trotskij'', ''Trockij'' and ''Trotzky''. (), was a Russian ...
. Volkow and her three sisters grew up in
Coyoacán Coyoacán ( , ) is a borough (''demarcación territorial'') in Mexico City. The former village is now the borough's "historic center". The name comes from Nahuatl and most likely means "place of coyotes", when the Aztecs named a pre-Hispani ...
in the house where Trotsky was killed (now the Leon Trotsky Museum). Volkow was educated at the Modern American School, in Mexico City, and graduated M.D. from the National University of Mexico, before her postdoctoral training in Psychiatry at
New York University New York University (NYU) is a private research university in New York City. Chartered in 1831 by the New York State Legislature, NYU was founded by a group of New Yorkers led by then- Secretary of the Treasury Albert Gallatin. In 1832, th ...
. In 2014, Volkow participated in an event organized by
The Moth The Moth is a non-profit group based in New York City dedicated to the art and craft of storytelling. Founded in 1997, the organization presents a wide range of theme-based storytelling events across the United States and abroad, often featuring ...
at a
World Science Festival The World Science Festival is an annual science festival produced by the World Science Foundation, a 501(c)(3) non-profit organization headquartered in New York City. There is also an Asia-Pacific event held in Brisbane, Australia. The foun ...
, where scientists, writers and artists told stories of their personal relationships with science. During this time, she discussed her family history and how it furthered her ambition to pursue science in order to positively influence others.


Career

During psychiatry residency, she worked on PET scan projects with psychiatrist Jonathan Brodie. After finishing psychiatry residency, she joined the faculty at the University of Texas Medical School at Houston, working on PET scan research projects in addition to clinical duties. She conducted research work with Professor Alan Swann, now at Baylor, leaving to Brookhaven in 1987. Volkow spent most of her professional career at the
Department of Energy A Ministry of Energy or Department of Energy is a government department in some countries that typically oversees the production of fuel and electricity; in the United States, however, it manages nuclear weapons development and conducts energy-re ...
’s
Brookhaven National Laboratory Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base and Japanese internment c ...
(BNL) in Upton, New York, where she held several leadership positions. She was first a researcher at BNL, and then Director of Nuclear Medicine, Director of the NIDA-DOE Regional Neuroimaging Center at BNL, and finally Associate Director for Life Sciences at BNL. She was also appointed as a Professor in the Department of Psychiatry at
Stony Brook University Stony Brook University (SBU), officially the State University of New York at Stony Brook, is a public research university in Stony Brook, New York. Along with the University at Buffalo, it is one of the State University of New York system' ...
and as Associate Dean for its Medical School. Volkow's imaging studies of the brains of people addicted to drugs have helped to clarify the mechanisms of
drug addiction Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use oft ...
. At Brookhaven,
positron emission tomography Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, ...
(PET) scanning was being used to study the brain in people with schizophrenia. When Volkow moved to the
University of Texas The University of Texas at Austin (UT Austin, UT, or Texas) is a public research university in Austin, Texas. It was founded in 1883 and is the oldest institution in the University of Texas System. With 40,916 undergraduate students, 11,075 ...
, studying patients with schizophrenia was not an option, but studying patients with cocaine addiction was possible. Volkow and colleagues studied the distribution of blood flow in the brain of chronic cocaine users and control patients who did use cocaine. They found decreased blood flow to the
prefrontal cortex In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA ...
of cocaine users, that continued after ten days of withdrawal from cocaine use. This research has played a part in changing the public's view of drug addiction, from that of a
moral A moral (from Latin ''morālis'') is a message that is conveyed or a lesson to be learned from a story or event. The moral may be left to the hearer, reader, or viewer to determine for themselves, or may be explicitly encapsulated in a maxim. ...
violation or
character flaw In the creation and criticism of fictional works, a character flaw or heroic flaw is a bias, limitation, imperfection, problem, personality disorder, vice, phobia, prejudice, or deficiency present in a character who may be otherwise very function ...
to an understanding that
pathological Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in th ...
changes to brain structure make it very difficult for addicts to give up their addictions. Volkow concludes that abnormalities in the prefrontal cortex create a feeling of need or craving that people with addictions find difficult to prevent. She argues that this makes it difficult to override compulsions by exercising
cognitive control In cognitive science and neuropsychology, executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and succ ...
. The main areas affected are the
orbitofrontal cortex The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making. In non-human primates it consists of the association cortex areas Brodmann area 11, 1 ...
, which maintains attention to goals, and the anterior
cingulate cortex The cingulate cortex is a part of the brain situated in the medial aspect of the cerebral cortex. The cingulate cortex includes the entire cingulate gyrus, which lies immediately above the corpus callosum, and the continuation of this in the c ...
, that mediates the capacity to monitor and select action plans. Both areas receive stimulation from
dopamine Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. Dopamine constitutes about 80% o ...
neurons that originate in the
ventral tegmental area The ventral tegmental area (VTA) (tegmentum is Latin for ''covering''), also known as the ventral tegmental area of Tsai, or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain. The VTA is the ...
. A steady influx of dopamine makes it difficult to shift attention away from the goal of attaining drugs. It also fastens attention to the
motivation Motivation is the reason for which humans and other animals initiate, continue, or terminate a behavior at a given time. Motivational states are commonly understood as forces acting within the agent that create a disposition to engage in goal-dire ...
al value of drugs, not pleasure. Volkow suggests that people with addictions are caught in a
vicious circle A vicious circle (or cycle) is a complex chain of events that reinforces itself through a feedback loop, with detrimental results. It is a system with no tendency toward equilibrium (social, economic, ecological, etc.), at least in the shor ...
of physical brain changes and the psychological consequences of those changes, leading to further changes. In 2003 Volkow became director of NIDA. Volkow is the first person from the NIH to visit the
Dalai Lama Dalai Lama (, ; ) is a title given by the Tibetan people to the foremost spiritual leader of the Gelug or "Yellow Hat" school of Tibetan Buddhism, the newest and most dominant of the four major schools of Tibetan Buddhism. The 14th and current D ...
at his residence in
Dharamshala Dharamshala (; also spelled Dharamsala) is the winter capital of Himachal Pradesh, India. It serves as administrative headquarters of the Kangra district after being relocated from Kangra, a city located away from Dharamshala, in 1855. The ...
,
Himachal Pradesh Himachal Pradesh (; ; "Snow-laden Mountain Province") is a state in the northern part of India. Situated in the Western Himalayas, it is one of the thirteen mountain states and is characterized by an extreme landscape featuring several pea ...
,
India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area, the List of countries and dependencies by population, second-most populous ...
. During this 2013 visit, Volkow took part in a dialogue with the Dalai Lama about addiction science, as part of a five-day conference sponsored by the
Mind and Life Institute The Mind & Life Institute is a US-registered, not-for-profit 501(c)(3) organization founded in 1991 to establish the field of contemplative sciences. Based in Charlottesville, Va., the institute “brings science and contemplative wisdom togeth ...
.


Awards and recognition

Volkow has been recognized for her contributions, both before and during her time at NIDA. The following are among the most significant: *Innovator of the Year. U.S. News & World Report, 2000. *
NEWSWEEK ''Newsweek'' is an American weekly online news magazine co-owned 50 percent each by Dev Pragad, its president and CEO, and Johnathan Davis (businessman), Johnathan Davis, who has no operational role at ''Newsweek''. Founded as a weekly print m ...
: Who's Next 2007, a list of 21 people predicted to be newsmakers in 2007. *The 2007 TIME 100. TIME's list of the 100 men and women whose power, talent or moral example is transforming the world. *The List of the Top 100 Most Powerful Women. The '' Washingtonian''s list of women who lead and lobby, educate and enlighten, and look for cures and pathways to a better world. *Washington's 100 Most Powerful Women, Washingtonian Magazine's list of females who've made it to the top. *Finalist for the Samuel J. Heyman Service to America Medal for the Science and Environment Medal (Sammies), Washington DC 2013. These awards recognize outstanding service and are considered among the most prestigious available to federal workers. *In 2007, NIDA and another NIH Institute (the
National Institute on Alcohol Abuse and Alcoholism The National Institute on Alcohol Abuse and Alcoholism (NIAAA), as part of the U.S. National Institutes of Health, supports and conducts biomedical and behavioural research on the causes, consequences, treatment, and prevention of alcoholism ...
) received an
Emmy Award The Emmy Awards, or Emmys, are an extensive range of awards for artistic and technical merit for the American and international television industry. A number of annual Emmy Award ceremonies are held throughout the calendar year, each with the ...
for HBO's ''The Addiction Project''. Nora Volkow represented NIDA in receiving the Emmy. * In 2011, Volkow received the Joan and Stanford Alexander Award in Psychiatry, from
Baylor College of Medicine Baylor College of Medicine (BCM) is a medical school and research center in Houston, Texas, within the Texas Medical Center, the world's largest medical center. BCM is composed of four academic components: the School of Medicine, the Graduate S ...
’s Menninger Department of Psychiatry and Behavioral Sciences.The prize is awarded to "a mental health professional who has made significant contributions in research, education and clinical or community service for people suffering from severe and persistent mental illness." Volkow's award was in recognition of her work in "demonstrating that drug addiction is a disease of the human brain", and "pioneering the use of brain imaging to investigate the toxic effects of drugs and their addictive properties." * Hispanic Scientist of the Year Award by Museum of Science & Industry (Tampa) in 2012, for promoting scientific understanding in the community and providing a role model for Hispanic youth. * In 2013, Volkow received the Distinguished Scientist Award from the Child Mind Institute, in recognition of her "outstanding contributions to brain development and psychopathology research." The prize is awarded to "a scientist whose lifelong commitment to research in mental health and developmental neuroscience has led to more effective, evidence-based treatments and a deeper understanding of psychiatric, addictive, and developmental disorders."


Personal life

Volkow is married to Stephen Adler, a radioimaging physicist at the
National Cancer Institute The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. T ...
.


Bibliography

* Online version is titled "Fighting back against the stigma of addiction".


References


External links


Nora D. Volkow, M.D.
Director's Page,
National Institute of Drug Abuse The National Institute on Drug Abuse (NIDA) is a United States federal government research institute whose mission is to "advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual a ...

Piore, Adam. "This Is Your Brain On Drugs."
Discover Magazine ''Discover'' is an American general audience science magazine launched in October 1980 by Time Inc. It has been owned by Kalmbach Publishing since 2010. History Founding ''Discover'' was created primarily through the efforts of ''Time'' m ...
, 30 October 2014. * * *
Why Bad Habits are Hard to Break
(
CBS CBS Broadcasting Inc., commonly shortened to CBS, the abbreviation of its former legal name Columbia Broadcasting System, is an American commercial broadcast television and radio network serving as the flagship property of the CBS Entertainm ...
60 Minutes ''60 Minutes'' is an American television news magazine broadcast on the CBS television network. Debuting in 1968, the program was created by Don Hewitt and Bill Leonard, who chose to set it apart from other news programs by using a unique st ...
interview, April 2012)'' -- Text only. Video access requires subscription.
Hooked: Why Bad Habits are Hard to Break
��Freely accessible video at 60 Minutes'
YouTube YouTube is a global online video sharing and social media platform headquartered in San Bruno, California. It was launched on February 14, 2005, by Steve Chen, Chad Hurley, and Jawed Karim. It is owned by Google, and is the second mo ...
Channel
Nora Volkow: Two Paths to the Future
''(Vanderbilt University Medical Center Article - February 2006)'' *

- the
Time 100 ''Time'' 100 (often stylized as ''TIME'' 100) is an annual listicle of the 100 most influential people in the world, assembled by the American news magazine ''Time''. First published in 1999 as the result of a debate among American academics, p ...
, 2007
Zuger, Abigail. "A General in the Drug War".
New York Times ''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...
, June 13, 2011.
Wingert, Pat. "Nora Volkow."
ewsweek, 24 December 2006. *
Why Is It So Damn Hard to Change?
by Rebecca Skloot, ''O, the Oprah Magazine''

''Oral History Program'', Office of NIH History, 6 April 2005. * {{DEFAULTSORT:Volkow, Nora 1956 births 20th-century American women scientists 21st-century American women scientists American addiction physicians American medical researchers American neuroscientists American people of Russian-Jewish descent American psychiatrists American women neuroscientists Brookhaven National Laboratory staff Hispanic and Latino American scientists Leon Trotsky Living people Mexican emigrants to the United States Mexican neuroscientists Mexican people of Russian-Jewish descent National Autonomous University of Mexico alumni People from Mexico City Scientific American people Women medical researchers Members of the National Academy of Medicine