Nobiletin is a

flavonoid Flavonoids (or bioflavonoids; from the Latin word ''flavus'', meaning yellow, their color in nature) are a class of polyphenolic secondary metabolites found in plants, and thus commonly consumed in the diets of humans. Chemically, flavonoids ...

isolated from

citrus peel Peel, also known as rind or skin, is the outer protective layer of a fruit or vegetable which can be peeled off. The rind is usually the botanical exocarp, but the term exocarp also includes the hard cases of nuts, which are not named peels si ...

s. It is an ''O''-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

Potential pharmacology

Nobiletin was found to potentially inhibit cartilage degradation. Nobiletin was shown to augment

AMPA receptor The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic receptor, ionotropic transmembrane receptor for glutamate (iGluR) that mediates fast synapse, synap ...

activity and long-term potentiation in cell culture. Synergistic chemopreventive effects of nobiletin and

atorvastatin Atorvastatin is a statin medication used to prevent cardiovascular disease in those at high risk and to treat abnormal lipid levels. For the prevention of cardiovascular disease, statins are a first-line treatment. It is taken by mouth. Common ...

on colon carcinogenesis have been described.

References

External links

Nobiletin
phytochemicals.info O-methylated flavones Flavonoids found in Rutaceae {{Aromatic-stub