NSP2 (NS35), is a
rotavirus
''Rotavirus'' is a genus of double-stranded RNA viruses in the family ''Reoviridae''. Rotaviruses are the most common cause of diarrhoeal disease among infants and young children. Nearly every child in the world is infected with a rotavirus ...
nonstructural RNA-binding protein
RNA-binding proteins (often abbreviated as RBPs) are proteins that bind to the double or single stranded RNA in cells and participate in forming ribonucleoprotein complexes.
RBPs contain various structural motifs, such as RNA recognition motif ...
that accumulates in cytoplasmic inclusions (
viroplasm
A viroplasm, sometimes called "virus factory" or "virus inclusion", is an inclusion body in a cell where viral replication and assembly occurs. They may be thought of as viral factories in the cell. There are many viroplasms in one infected cell, w ...
s) and is required for genome replication.
NSP2 is closely associated in vivo with the viral replicase.
The non-structural protein
NSP5 plays a role in the structure of
viroplasm
A viroplasm, sometimes called "virus factory" or "virus inclusion", is an inclusion body in a cell where viral replication and assembly occurs. They may be thought of as viral factories in the cell. There are many viroplasms in one infected cell, w ...
s mediated by its interaction with
NSP2.
References
Rotaviruses
Viral nonstructural proteins
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