Neurogenic locus notch homolog protein 1 (Notch 1) is a protein encoded in humans by the ''NOTCH1''
gene.
Notch 1 is a single-pass transmembrane
receptor.
Function
This gene encodes a member of the
Notch family. Members of this Type 1
transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple
epidermal growth factor
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-k Da and has 53 amino acid residues and three intramolecular disulfide bonds.
EGF was originally descr ...
-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an
evolutionarily conserved
In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids ( DNA and RNA) or proteins across species ( orthologous sequences), or within a genome ( paralogous sequences), or between donor and receptor tax ...
intercellular
signaling pathway that regulates interactions between physically adjacent cells. In ''
Drosophila'', notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in humans, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the
trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
A deficiency can be associated with
bicuspid aortic valve.
There is evidence that activated Notch 1 and
Notch 3
Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the ''NOTCH3'' gene.
Function
This gene encodes the third discovered human homologue of the ''Drosophila melanogaster'' type I membrane protein notch ...
promote differentiation of progenitor cells into
astroglia.
Notch 1, when activated before birth, induces
radial glia differentiation,
but postnatally induces the differentiation into
astrocytes.
One study shows that Notch-1 cascade is activated by
Reelin in an unidentified way.
Reelin and Notch1 cooperate in the development of the
dentate gyrus, according to another.
Interactions
NOTCH1 has been shown to
interact with:
*
GSK3B,
*
Lck,
*
MAML1,
*
Mothers against decapentaplegic homolog 3
*
NFKB1,
*
NOV Nov or NOV may refer to:
* November, the 11th month of the year in the Julian and Gregorian calendars
* Nav, Asalem (also , Nov or Nāv), a village in Gilan Province, Iran
* Nov, Golan Heights, an Israeli moshav (a cooperative agricultural communi ...
,
*
RBPJ,
*
SNW1,
*
Ubiquitin C,
and
*
YY1.
*
USP10.
References
Further reading
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External links
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NOTCH1
{{Notch signaling pathway