(born March 25, 1946) is a Japanese

neuroscientist A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, neural circuits, and glial ...

and

cell biologist Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and ...

famous for research on the

kinesin superfamily A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a type of e ...

motor proteins Motor proteins are a class of molecular motors that can move along the cytoplasm of cells. They convert chemical energy into mechanical work by the hydrolysis of ATP. Flagellar rotation, however, is powered by a proton pump. Cellular function ...

. He has been President and Chair of the Board of Trustees at the

Human Frontier Science Program } The International Human Frontier Science Program Organization (HFSPO) is a non-profit organization, based in Strasbourg, France, that funds basic research in life sciences. The organization implements the Human Frontier Science Program (HFSP) and ...

since 2012.

Contribution

Hirokawa's work is mostly focused on the molecular mechanisms involved in transporting materials within nerve cells, in particular in his discovery of many of the functions of the

Kinesin A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases, a type of enzy ...

superfamily of

molecular motors Molecular motors are natural (biological) or artificial molecular machines that are the essential agents of movement in living organisms. In general terms, a motor is a device that consumes energy in one form and converts it into motion or mech ...

Biography

Hirokawa was born in

Yokosuka, Kanagawa is a city in Kanagawa Prefecture, Japan. , the city has a population of 409,478, and a population density of . The total area is . Yokosuka is the 11th most populous city in the Greater Tokyo Area, and the 12th in the Kantō region. The city ...

and received his M.D. in 1971 and his Ph.D. in 1978 from The

University of Tokyo , abbreviated as or UTokyo, is a public research university located in Bunkyō, Tokyo, Japan. Established in 1877, the university was the first Imperial University and is currently a Top Type university of the Top Global University Project b ...

in Japan; from 1979 to 1983 he served as a Postdoctoral Fellow at

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It con ...

and as a research Assistant professor and an associate professor at

Washington University in St. Louis Washington University in St. Louis (WashU or WUSTL) is a private research university with its main campus in St. Louis County, and Clayton, Missouri. Founded in 1853, the university is named after George Washington. Washington University is r ...

."未踏の細胞を観察する" Biography of Nobutaka Hirokawa

/ref> On returning to Japan, he was appointed Professor and Chairman of Cell Biology and

Anatomy Anatomy () is the branch of biology concerned with the study of the structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having it ...

at the Graduate School of Medicine, The University of Tokyo, where he served as the Dean from 2003 to 2007. He is now holds a Distinguished Project Professor at the same institution.

Publications

Hirokawa published numerous papers include the following *Hirokawa, N. Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method.

Journal of Cell Biology The ''Journal of Cell Biology'' is a peer-reviewed scientific journal published by Rockefeller University Press. History In the early 1950s, a small group of biologists began to explore intracellular anatomy using the emerging technology of ele ...

94(1): 129-142, 1982. *Hirokawa, N., K.K. Pfister, H. Yorifuji, M.C. Wagner, S.T. Brady, and G.S. Bloom. Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration. Cell 56(5): 867-878, 1989 *Okada, Y., H. Yamazaki, Y. Sekine-Aizawa, and N. Hirokawa. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell 81(5): 769-780, 1995. *Hirokawa, N. Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279(5350): 519-526, 1998. *Nonaka, S., Y. Tanaka, Y. Okada, S. Takeda, A. Harada, Y. Kanai, M. Kido, and N. Hirokawa. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95(6): 829-837, 1998. *Okada, Y., and N. Hirokawa. A Processive Single-Headed Motor: Kinesin Superfamily Protein KIF1A. Science 283: 1152–1157, 1999. *Setou, M., T. Nakagawa, D.H. Seog, and N. Hirokawa. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288(5472): 1796–1802, 2000. *Kikkawa, M., E.P. Sablin, Y. Okada, H. Yajima, R.J. Fletterick, and N. Hirokawa. Switch-based mechanism of kinesin motors. Nature 411(6836): 439-445, 2001. *Homma, N., Y. Takei, Y. Tanaka, T. Nakata, S. Terada, M. Kikkawa, Y. Noda, and N. Hirokawa. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114: 229-239, 2003. *Nitta, R., M. Kikkawa, Y. Okada, and N. Hirokawa. KIF1A alternately uses two loops to bind microtubules. Science 305: 678-683, 2004. *Hirokawa, N. and R. Takemura. Molecular motors and mechanisms of directional transport in neurons.

Nature Reviews Neuroscience ''Nature Reviews Neuroscience'' is a monthly peer-reviewed review journal published by Nature Portfolio. It was established in 2000. The editor-in-chief is Darran Yates. Abstracting and indexing The journal is abstracted and indexed in: *PubMed/ ...

6: 201-214, 2005. *Hirokawa, N., Y. Tanaka, Y. Okada and S. Takeda. Nodal flow and the generation of left-right asymmetry. (Review Article) Cell 125(1): 33-45, 2006. *Midorikawa, R., Y. Takei, and N. Hirokawa. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Cell 125: 371-383, 2006

Honors and awards

Hirokawa received several honors and awards include the following *

Asahi Prize The , established in 1929, is an award presented by the Japanese newspaper ''Asahi Shimbun'' and Asahi Shimbun Foundation to honor individuals and groups that have made outstanding accomplishments in the fields of arts and academics and have greatl ...

, ''

Asahi Shimbun is one of the four largest newspapers in Japan. Founded in 1879, it is also one of the oldest newspapers in Japan and Asia, and is considered a newspaper of record for Japan. Its circulation, which was 4.57 million for its morning edition a ...

'' (1995) * Japan Academy Prize,

Japan Academy The Japan Academy ( Japanese: 日本学士院, ''Nihon Gakushiin'') is an honorary organisation and science academy founded in 1879 to bring together leading Japanese scholars with distinguished records of scientific achievements. The Academy is ...

(1999) *Foreign member,

European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...

(2003) *Member,

(2004) * Person of Cultural Merit (2013)

References

External links

Hirokawa's Lab, Graduate School of Medicine, University of Tokyo
{{DEFAULTSORT:Hirokawa, Nobutaka Japanese biologists Japanese neuroscientists Cell biologists Members of the European Molecular Biology Organization Academic staff of the University of Tokyo University of Tokyo alumni People from Yokosuka, Kanagawa 1946 births Living people Washington University in St. Louis faculty