__NOTOC__
Nkx2-2as (Nkx2-2 antisense) is a
long non-coding RNA. It is located in the
cytoplasm of the
cell. Nkx2-2as is involved in
Neural development
The development of the nervous system, or neural development (neurodevelopment), refers to the processes that generate, shape, and reshape the nervous system of animals, from the earliest stages of embryonic development to adulthood. The fie ...
. Overexpression of Nkx2-2as results in increased levels of expression of the
homeobox
A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. For instance, mutations in a homeobox may change large-scale anatomical features of the full- ...
gene
Nkx2-2
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the ''NKX2-2'' gene.
Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome ...
and enhances induction of the
differentiation of
oligodendrocytes.
Besides Nkx2-2, Nkx2-2as may also regulate the expression of other genes.
See also
*
Long non-coding RNA
References
Further reading
*
{{refend
External links
MGI entry for Nkx2-2as
Non-coding RNA