Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at

Albert Einstein College of Medicine Albert Einstein College of Medicine is a research-intensive medical school located in the Morris Park neighborhood of the Bronx in New York City. Founded in 1953, Einstein operates as an independent degree-granting institution as part of t ...

(Einstein). He also directs the

Longevity The word " longevity" is sometimes used as a synonym for "life expectancy" in demography. However, the term ''longevity'' is sometimes meant to refer only to especially long-lived members of a population, whereas ''life expectancy'' is always d ...

Genes Project, a genetics study of over 600 families of centenarians and their children. The participants are all

Ashkenazi Jews Ashkenazi Jews ( ; he, יְהוּדֵי אַשְׁכְּנַז, translit=Yehudei Ashkenaz, ; yi, אַשכּנזישע ייִדן, Ashkenazishe Yidn), also known as Ashkenazic Jews or ''Ashkenazim'',, Ashkenazi Hebrew pronunciation: , singu ...

, a group selected for their

genetic homogeneity Genetic may refer to: *Genetics, in biology, the science of genes, heredity, and the variation of organisms **Genetic, used as an adjective, refers to genes ***Genetic disorder, any disorder caused by a genetic mutation, whether inherited or de nov ...

, which makes it easier to identify significant genetic variations. Barzilai found that many of the centenarians had very high levels of HDL. Barzilai also co-founded of CohBar, Inc., a biotechnology company developing mitochondria based therapeutics to treat diseases associated with aging. Barzilai discovered several “ longevity genes” in humans that were validated by others. These include variants in genes involved in cholesterol metabolism (

CETP Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It collects triglycerides from very-low-de ...

and

APOC3 Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the ''APOC3'' gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such ...

), metabolism ( ADIPOQ and

TSHR The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH recep ...

) and growth (

IGF1R The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 ( IGF-1) and by a related hormone called IGF-2. ...

). These genes appear to protect centenarians against major age-related diseases, such as

cardiovascular disease Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, h ...

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

type 2 diabetes Type 2 diabetes, formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. Common symptoms include increased thirst, frequent urination, ...

and

dementia Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affe ...

. Treatments for

age-related diseases An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing senescence. They are essentially complications of senescence, distinguished from the aging proc ...

were under development based on Barzilai’s work. A collaboration with Merck conducted early-stage

clinical trials Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

but ultimately abandoned

Anacetrapib Anacetrapib is a CETP inhibitor which was being developed to treat elevated cholesterol levels in an effort to prevent cardiovascular disease. In 2017 its development was abandoned by Merck. Evidence In 2017 REVEAL trial anacetrapib was shown t ...

. The diabetes research is led by CohBar Inc., a biotech company that Barzilai helped co-found. In addition to his “longevity gene” research, Barzilai studies key mechanisms involved in the biology of aging, including how nutrients and genetics influence lifespan. He has also proposed

metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome. ...

as a tool to target aging and has run the Metformin in Longevity Study (completed May 2018) He is also investigating how mental decline and personality affect longevity. Barzilai was born in

Haifa Haifa ( he, חֵיפָה ' ; ar, حَيْفَا ') is the third-largest city in Israel—after Jerusalem and Tel Aviv—with a population of in . The city of Haifa forms part of the Haifa metropolitan area, the third-most populous metropol ...

Israel Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...

. During his national service in the

Israel Defense Forces The Israel Defense Forces (IDF; he, צְבָא הַהֲגָנָה לְיִשְׂרָאֵל , ), alternatively referred to by the Hebrew-language acronym (), is the national military of the Israel, State of Israel. It consists of three servic ...

, he served as a medical instructor. In 1976, he served as a medical officer in

Operation Entebbe Operation Entebbe, also known as the Entebbe Raid or Operation Thunderbolt, was a counter-terrorist hostage-rescue mission carried out by commandos of the Israel Defense Forces (IDF) at Entebbe Airport in Uganda on 4 July 1976. A week earl ...

. He was the Israeli army's chief medic from 1977 to 1985. He studied medicine at the

Technion – Israel Institute of Technology The Technion – Israel Institute of Technology ( he, הטכניון – מכון טכנולוגי לישראל) is a public research university located in Haifa, Israel. Established in 1912 under the dominion of the Ottoman Empire, the Technion ...

, obtaining his MD in 1985. He interned at

Rambam Medical Center Rambam Health Care Campus ( he, רמב"ם - הקריה הרפואית לבריאות האדם) commonly called Rambam Hospital, is a teaching hospital in the Bat Galim neighborhood of Haifa, Israel founded in 1938, 10 years before the establishme ...

in Haifa,

Hadassah Medical Center Hadassah Medical Center ( he, הָמֶרְכָּז הָרְפוּאִי הֲדַסָּה) is an Israeli medical organization established in 1934 that operates two university hospitals in Jerusalem – one in Ein Karem and one in Mount Scopus –, ...

in Jerusalem, and the

Royal Free Hospital The Royal Free Hospital (also known simply as the Royal Free) is a major teaching hospital in the Hampstead area of the London Borough of Camden. The hospital is part of the Royal Free London NHS Foundation Trust, which also runs services at Barn ...

London London is the capital and largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary down to the North Sea, and has been a majo ...

. He first came to the U.S. in 1987 as a resident at

Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...

. He joined Einstein in 1993 as an instructor of medicine (

endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

).USA: Nir Barzilai (Technion, Hadassah), the man who wants to beat back aging
/ref>

References

{{DEFAULTSORT:Barzilai, Nir Living people Israeli geneticists Israeli medical researchers Technion – Israel Institute of Technology alumni Albert Einstein College of Medicine faculty 1955 births