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The NhaD family
TC# 2.A.62
belongs to the Ion Transporter (IT) Superfamily. A representative list of proteins belonging to the NhaD family can be found in th
Transporter Classification Database
The NhaD Na⁺/H⁺ antiporter has been characterized from two ''Vibrio'' species: '' V. parahaemolyticus'' and '' V. cholerae'' and in the haloalkaliphile, ''

Alkalimonas amylolytica ''Alkalimonas'' is a genus in the phylum Pseudomonadota (Bacteria). Etymology The name ''Alkalimonas'' derives from: : New Latin noun ''alkali'' (from Arabic ''al''-''qaliy''), ashes of salt wort; Greek feminine gender noun '' monas (μονά� ...

''. These proteins and their homologues are 400-500 aas long and exhibit 10-13 TMSs. They catalyze Na⁺/H⁺ and Li⁺/H⁺ antiport. They exhibit activity at basic pH (8-10) with no activity at pH 7.5. The ''Amylolytica'' antiporter has low Na⁺ affinity and has optimal activity at 600 mM Na⁺. Homologues are found in

Pseudomonadota Pseudomonadota (synonym Proteobacteria) is a major phylum of Gram-negative bacteria. The renaming of phyla in 2021 remains controversial among microbiologists, many of whom continue to use the earlier names of long standing in the literature. The ...

of all groups, ''

Flavobacteriia The class Flavobacteriia is composed of a single order of environmental bacteria. According to Bernardet ''et al''., Flavobacteriia are Gram-negative aerobic rods, 2–5 μm long, 0.3–0.5 μm wide, with rounded or tapered end ...

'', and ''

Chlamydia Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium ''Chlamydia trachomatis''. Most people who are infected have no symptoms. When symptoms do appear they may occur only several wee ...

.'' Distant homologues of the IT superfamily are ubiquitous. The generalized reaction catalyzed by NhaD is:

nH⁺ (in) + mNa⁺ (out) ⇌ nH⁺ (out) + mNa⁺ (in).

See also

* Sodium-Proton antiporter *

Antiporter An antiporter (also called exchanger or counter-transporter) is a cotransporter and integral membrane protein involved in secondary active transport of two or more different molecules or ions across a phospholipid membrane such as the plasma memb ...

* Transporter Classification Database

Further reading

* Barrero-Gil, Javier; Rodríguez-Navarro, Alonso; Benito, Begoña (2007-01-01)
"Cloning of the PpNHAD1 transporter of Physcomitrella patens, a chloroplast transporter highly conserved in photosynthetic eukaryotic organisms"
''Journal of Experimental Botany'' 58(11): 2839–2849. doi: 10.1093/jxb/erm094.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

PMID PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

&nbs
17617660
* Kurz, Matthias; Brünig, Anika N. S.; Galinski, Erwin A. (2006-01-01)
"NhaD type sodium/proton-antiporter of Halomonas elongata: a salt stress response mechanism in marine habitats?"
''Saline Systems'' 2: 10. doi: 10.1186/1746-1448-2-10.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

&nbs
1746-1448
PMC&nbs
1552076

PMID PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

&nbs
16872527
* Liu, Jun; Xue, Yanfen; Wang, Quanhui; Wei, Yi; Swartz, Talia H.; Hicks, David B.; Ito, Masahiro; Ma, Yanhe; Krulwich, Terry A. (2005-11-01)
"The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment"
''Journal of Bacteriology'' 187 (22): 7589–7595. doi: 10.1128/JB.187.22.7589-7595.2005.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

&nbs
0021-9193
* Melo, Ana M. P.; Felix, Nuno A. M.; Carita, João N.; Saraiva, Lígia M.; Teixeira, Miguel (2006-09-29
"The Na+/H+ antiporter of the thermohalophilic bacterium Rhodothermus marinus"
''Biochemical and Biophysical Research Communications'' 348 (3): 1011–1017. doi: 10.1016/j.bbrc.2006.07.134.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

PMID PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

&nbs
16904646
* Zhong, Nai-Qin; Han, Li-Bo; Wu, Xiao-Min; Wang, Li-Li; Wang, Fang; Ma, Yan-He; Xia, Gui-Xian (2012-06-01)
"Ectopic expression of a bacterium NhaD-type Na+/H+ antiporter leads to increased tolerance to combined salt/alkali stresses"
''Journal of Integrative Plant Biology'' 54 (6): 412–421. doi: 10.1111/j.1744-7909.2012.01129.x.

ISSN An International Standard Serial Number (ISSN) is an eight-digit serial number used to uniquely identify a serial publication, such as a magazine. The ISSN is especially helpful in distinguishing between serials with the same title. ISSNs ...

PMID PubMed is a free search engine accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics. The United States National Library of Medicine (NLM) at the National Institutes of Health maintain the ...

References

{{CCBYSASource, sourcepath=http://www.tcdb.org/search/result.php?tc=2.A.62, sourcearticle=2.A.62 The NhaD Na+:H+ Antiporter (NhaD) Family, revision=699838558 Protein families Membrane proteins Transmembrane proteins Transmembrane transporters Transport proteins Integral membrane proteins