Neutral Amino Acid Transporter
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An amino acid transporter is a
membrane transport protein A membrane transport protein (or simply transporter) is a membrane protein involved in the movement of ions, small molecules, and macromolecules, such as another protein, across a biological membrane. Transport proteins are integral transmembran ...
that transports
amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...
s. They are mainly of the solute carrier family.


Families

There are several families that function in amino acid transport, some of these include:
TC# 2.A.3
- Amino Acid-Polyamine-Organocation (APC) Superfamily
TC# 2.A.18
- Amino Acid/Auxin Permease (AAAP) Family
TC# 2.A.23
- Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family
TC# 2.A.26
- Branched Chain Amino Acid:Cation Symporter (LIVCS) Family
TC# 2.A.42
- Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family
TC# 2.A.78
- Branched Chain Amino Acid Exporter (LIV-E) Family
TC# 2.A.95
- 6TMS Neutral Amino Acid Transporter (NAAT) Family
TC# 2.A.118
- Basic Amino Acid Antiporter (ArcD) Family
TC# 2.A.120
- Putative Amino Acid Permease (PAAP) Family


Solute carrier family examples

* (1) high affinity glutamate and neutral amino acid transporter * (3)
heavy subunits of heteromeric amino acid transporters Heavy may refer to: Measures * Heavy (aeronautics), a term used by pilots and air traffic controllers to refer to aircraft capable of 300,000 lbs or more takeoff weight * Heavy, a characterization of objects with substantial weight * Heavy, ...
* (6)
Bacterial Leucine Transporter Bacterial Leucine Transporter (LeuT) is a bundled twelve alpha helix protein which belongs to the family of transporters that shuttle amino acids in and out of bacterial cells. Specialized in small hydrophobic amino acids such as leucine and alani ...
(LeuT) * (7) cationic amino acid transporter/glycoprotein-associated * (15)
proton oligopeptide cotransporter A proton is a stable subatomic particle, symbol , H+, or 1H+ with a positive electric charge of +1 ''e'' elementary charge. Its mass is slightly less than that of a neutron and 1,836 times the mass of an electron (the proton–electron mass ...
* (17)
vesicular glutamate transporter Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the ''SLC17A7'' gene. The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-r ...
* (18)
vesicular amine transporter The vesicular monoamine transporter (VMAT) is a transport protein integrated into the membranes of synaptic vesicles of synapse, presynaptic neurons. It transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epin ...
* (25) some
mitochondrial carrier Mitochondrial carriers are proteins from solute carrier family 25 which transfer molecules across the membranes of the mitochondria. Mitochondrial carriers are also classified in thTransporter Classification Database The Mitochondrial Carrier (M ...
s * (26)
multifunctional anion exchanger An MFP (multi-function product/printer/peripheral), multi-functional, all-in-one (AIO), or multi-function device (MFD), is an office machine which incorporates the functionality of multiple devices in one, so as to have a smaller footprint in a ...
* (32) ''vesicular inhibitory amino acid transporter'' * (36) proton-coupled amino acid transporter * (38) System A & N, sodium-coupled neutral amino acid transporter


VIAAT

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles. esicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in TC6 Cells, Mouse Clonal -Cells, and -Cells of Islets of LangerhansDiabetes 52:2066-2074, 2003


Human proteins containing this domain

SLC32A1 Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the ''SLC32A1'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meanin ...
;
SLC36A1 Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the ''SLC36A1'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ...
;
SLC36A2 Proton-coupled amino acid transporter 2 is a protein which in humans is encoded by the ''SLC36A2'' gene. Function SLC36A2 transports small amino acids (glycine, alanine, and proline) and also the D-enantiomers and select amino acid derivative ...
; SLC36A3; SLC36A4;
SLC38A1 Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the ''SLC38A1'' gene. Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, an ...
;
SLC38A2 Sodium-coupled neutral amino acid transporter 2 is a protein that in humans is encoded by the ''SLC38A2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." m ...
;
SLC38A3 Sodium-coupled neutral amino acid transporter 3 is a protein that in humans is encoded by the ''SLC38A3'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." m ...
; SLC38A4;
SLC38A5 Solute carrier family 38 member 5 is a protein that in humans is encoded by the SLC38A5 gene. Function The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, ...
; SLC38A6.


See also

* Solute carrier family * Amino acid transport * Amino acid transport, acidic * Amino acid transport, basic *
Amino acid transport disorder Amino acid transport disorders are medical conditions associated with a failure of amino acids to be absorbed from the kidney or intestine. An example is Hartnup disease Hartnup disease (also known as "pellagra-like dermatosis" and "Hartnup ...
*
Amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...
* Transporter Classification Database


References

{{Glutamate metabolism and transport modulators Solute carrier family