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Neuropeptide Y receptor type 2 (Y2R) is a member of the
neuropeptide Y receptor Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are invo ...
family of
G-protein coupled receptors G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of protein family, evolution ...
, that in humans is encoded by the ''NPY2R''
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.


Selective ligands


Agonists

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Neuropeptide Y Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the ma ...
(endogenous agonist, non subtype selective) * Neuropeptide Y fragment 13-36 (NPY2 selective agonist) *
Peptide YY Peptide YY (PYY) also known as peptide tyrosine tyrosine is a peptide that in humans is encoded by the gene. Peptide YY is a short (36-amino acid) peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, a ...
* Peptide YY 3-36 fragment


Antagonists

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BIIE-0246 BIIE-0246 is a drug used in scientific research which acts as a potent and selective antagonist for the Neuropeptide Y receptor Y2. It was one of the first non-peptide Y2-selective antagonists developed, and remains among the most widely used t ...
(CAS# 246146-55-4) * JNJ 5207787 (CAS# 683746-68-1) * SF 11 (CAS# 443292-81-7)


See also

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Neuropeptide Y receptor Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are invo ...


References


External links

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Further reading

* * * * * * * * * * * * * * * G protein-coupled receptors {{transmembranereceptor-stub