Neuropeptide Y receptor type 1 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''NPY1R''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Selective ligands

Agonists

Neuropeptide Y Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the ma ...

(endogenous agonist, non subtype selective) *

Peptide YY Peptide YY (PYY) also known as peptide tyrosine tyrosine is a peptide that in humans is encoded by the gene. Peptide YY is a short (36-amino acid) peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, a ...

Antagonists

;Peptide * BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8) * GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4) ;Non-peptide * BIBO-3304 (CAS# 191868-14-1) *

BIBP-3226 BIBP-3226 is a drug used in scientific research which acts as a potent and selective antagonist for both the Neuropeptide Y receptor Y1 and also the neuropeptide FF receptor. It was the first non-peptide antagonist developed for the Y1 recepto ...

(CAS# 159013-54-4) * PD-160,170 (CAS# 181468-88-2)

Available Structures

5ZBH
(Neuropeptide Y1 bound to antagonist BMS-193835)
5ZBQ
(Neuropeptide Y1 bound to antagonist UR-MK299)

References

External links

* * G protein-coupled receptors {{transmembranereceptor-stub