Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4

EF hand The EF hand is a helix–loop–helix structural domain or ''motif'' found in a large family of calcium-binding proteins. The EF-hand motif contains a helix–loop–helix topology, much like the spread thumb and forefinger of the human hand, in ...

motifs (out of which only 2 or 3 bind calcium) and an N- myristoyl group.

Members of NCS family

* Highly evolutionarily conserved * NCS1 (Frequenin) * VILIP-1 (Visinin-like-protein-1) * HPCAL4 (Visinin-like-protein-2) *

HPCAL1 Hippocalcin-like protein 1 is a protein that in humans is encoded by the ''HPCAL1'' gene. The protein encoded by this gene is a member of the neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to h ...

(Visinin-like-protein-3) *

hippocalcin Hippocalcin is a protein that in humans is encoded by the ''HPCA'' gene. Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippoc ...

* neurocalcin *

recoverin Recoverin (abbreviated Recov) is a 23 kilodalton (kDa) neuronal calcium-binding protein that is primarily detected in the photoreceptor cells of the eye. It plays a key role in the inhibition of rhodopsin kinase, a molecule which regulates the p ...

Guanylate cyclase activator A guanylate cyclase activator (or "GUCA") is one of group of proteins which upregulates guanylate cyclase Guanylate cyclase (EC 4.6.1.2, also known as guanyl cyclase, guanylyl cyclase, or GC; systematic name GTP diphosphate-lyase (cyclizing; ...

proteins (GCAPs) * Potassium Channel interacting proteins (KChIPs 1–4), including: KCNIP1,

KCNIP2 Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the ''KCNIP2'' gene. Function This gene encodes a member of the family of voltage-gated potassium ( Kv) channel-interacting proteins (KCNIPs, also ...

Calsenilin Calsenilin is a protein that in humans is encoded by the ''KCNIP3'' gene. Function This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of pro ...

or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein),

KCNIP4 Kv channel-interacting protein 4 is a protein that in humans is encoded by the ''KCNIP4'' gene. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch o ...

References

External links

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NCS proteins
Protein families {{protein-stub