SPX can refer to:
*
S&P 500
The Standard and Poor's 500, or simply the S&P 500, is a stock market index tracking the stock performance of 500 leading companies listed on stock exchanges in the United States. It is one of the most commonly followed equity indices and in ...
, a stock market index
*
Sequenced Packet Exchange, a networking protocol
* IATA code of
Sphinx International Airport, an airport in Giza, Egypt
*
Small Press Expo
The Small Press Expo (SPX) is an American alternative comics convention. A registered 501(c)(3) that was created in 1994, every year since its inception, SPX has put on a festival, known as The Expo, that provides a forum for artists, writers a ...
, an alternative comics convention
*
SpaceX
Space Exploration Technologies Corp., commonly referred to as SpaceX, is an America, American space technology company headquartered at the SpaceX Starbase, Starbase development site in Starbase, Texas. Since its founding in 2002, the compa ...
(SpX), a rocket manufacturer
*
Sports Performance eXtreme, a sports shoe and clothing brand
*
SPX Corporation, a Fortune 500 electronics company
*
St. Pius X, the 257th Pope of the Roman Catholic Church.
**
St Pius X College, Sydney, Australia
**
St. Pius X Seminary, Roxas City, Philippines
*
Superphénix, a nuclear power plant
* ''
Skulduggery Pleasant: Resurrection'', the 10th book in the ''
Skulduggery Pleasant'' series
* A file extension used for
Speex
{{More citations needed, date=May 2025
The Speex project is an attempt to create a free software speech codec, unencumbered by patent restrictions. Speex is licensed under the BSD License and is used with the Xiph.org Foundation's Ogg containe ...
-encoded audio files
* The National Rail code for
St Pancras International railway station in Greater London
* The former IATA and FAA code for
Houston Gulf Airport
{{disambig