1-(1-Naphthyl)piperazine (1-NP) is a
drug which is a
phenylpiperazine
1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.
List phenylpiperazine derivativesAlp ...
derivative
In mathematics, the derivative of a function of a real variable measures the sensitivity to change of the function value (output value) with respect to a change in its argument (input value). Derivatives are a fundamental tool of calculus. ...
. It acts as a non-
selective, mixed
serotonergic
Serotonergic () or serotoninergic () means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter. A synapse is serotonergic if it uses serotonin as its neurotransmitter. A serotonergic neuron ''produces'' serotonin. A substance is ...
agent, exerting
partial agonism
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonistic ef ...
at the
5-HT1A,
5-HT1B,
5-HT1D,
5-HT1E, and
5-HT1F receptors,
while
antagonizing the
5-HT2A,
5-HT2B, and
5-HT2C receptors.
It has also been shown to possess high
affinity
Affinity may refer to:
Commerce, finance and law
* Affinity (law), kinship by marriage
* Affinity analysis, a market research and business management technique
* Affinity Credit Union, a Saskatchewan-based credit union
* Affinity Equity Par ...
for the
5-HT3,
5-HT5A,
5-HT6, and
5-HT7 receptors,
and may bind to
5-HT4 and the
SERT as well.
In animals it produces effects including
hyperphagia
Polyphagia or hyperphagia is an abnormally strong, incessant sensation of hunger or desire to eat often leading to overeating. In contrast to an increase in appetite following exercise, polyphagia does not subside after eating and often leads to ...
,
hyperactivity
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterised by excessive amounts of inattention, hyperactivity, and impulsivity that are pervasive, impairing in multiple contexts, and otherwise age-inappr ...
,
and
anxiolysis
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
,
of which are all likely mediated predominantly or fully by blockade of the 5-HT
2C receptor.
See also
*
Substituted piperazine
Substituted piperazines are a class of chemical compounds based on a piperazine core. Some are used as recreational drugs and some are used in scientific research.
List of substituted piperazines
Benzylpiperazines
File:Benzylpiperazine.svg, 1- ...
*
Diphenylpiperazine
*
Phenylpiperazine
1-Phenylpiperazine is a simple chemical compound featuring a phenyl group bound to a piperazine ring. The suffix ‘-piprazole’ is sometimes used in the names of drugs to indicate they belong to this class.
List phenylpiperazine derivativesAlp ...
*
Quipazine
Quipazine is a serotonergic drug of the piperazine group which is used in scientific research. It was originally intended as an antidepressant but never developed for medical use.
Pharmacology
Pharmacodynamics
Quipazine is a serotonin reuptake ...
References
{{Piperazines
1-Naphthyl compounds
Serotonin receptor antagonists
Serotonin receptor agonists
Naphthylpiperazines