A nanoprobe is an

optical Optics is the branch of physics that studies the behaviour and properties of light, including its interactions with matter and the construction of instruments that use or detect it. Optics usually describes the behaviour of visible, ultraviole ...

device developed by tapering an

optical fiber An optical fiber, or optical fibre in Commonwealth English, is a flexible, transparent fiber made by drawing glass (silica) or plastic to a diameter slightly thicker than that of a human hair. Optical fibers are used most often as a means to ...

to a tip measuring 100 nm = 1000

angstrom The angstromEntry "angstrom" in the Oxford online dictionary. Retrieved on 2019-03-02 from https://en.oxforddictionaries.com/definition/angstrom.Entry "angstrom" in the Merriam-Webster online dictionary. Retrieved on 2019-03-02 from https://www.m ...

s wide. Also, a very thin coating of

silver nanoparticle Silver nanoparticles are nanoparticles of silver of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface to bulk silve ...

s helps to enhance the

Raman scattering Raman scattering or the Raman effect () is the inelastic scattering of photons by matter, meaning that there is both an exchange of energy and a change in the light's direction. Typically this effect involves vibrational energy being gained by a ...

effect of the light. (The phenomenon of light reflection from an object when illuminated by a laser light is referred to as Raman scattering.) The reflected light demonstrates vibration energies unique to each object (samples in this case), which can be characterised and identified. The

silver Silver is a chemical element with the Symbol (chemistry), symbol Ag (from the Latin ', derived from the Proto-Indo-European wikt:Reconstruction:Proto-Indo-European/h₂erǵ-, ''h₂erǵ'': "shiny" or "white") and atomic number 47. A soft, whi ...

nanoparticles in this technique provides for the rapid oscillations of electrons, adding to vibration energies, and thus enhancing Raman Scattering—commonly known as surface-enhanced Raman scattering (

SERS Sers may refer to: * Sers, Armenia * Sers, Charente, France * Sers, Hautes-Pyrénées, France * Sers, Tunisia SERS may refer to: * Surface enhanced Raman spectroscopy (SERS) * Selective En bloc Redevelopment Scheme The Selective En bloc Re ...

). These SERS nanoprobes produce higher electromagnetic fields enabling higher signal output—eventually resulting in accurate detection and analysis of samples. The term nanoprobe also refers more generically to any chemical or biological technique that deals with nanoquantitles, that is, introducing or extracting substances measured in nanoliters or nanograms rather than microliters or micrograms. For example: * Introducing

nanoparticles A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 1 ...

in aqueous solution to serve as nanoprobes in electrospray ionization mass spectrometry * Extracting nanoquantities of neurochemicals via in vivo

microdialysis Microdialysis is a minimally-invasive sampling technique that is used for continuous measurement of free, unbound analyte concentrations in the extracellular fluid of virtually any tissue. Analytes may include endogenous molecules (e.g. neurotra ...

* Using gold-based metallic nanoprobes for

Theranostics Personalized medicine, also referred to as precision medicine, is a medical model that separates people into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on thei ...

(therapeutic diagnostics) In semiconductor manufacturing,

nanoprobing Nanoprobing is method of extracting device electrical parameters through the use of nanoscale tungsten wires, used primarily in the semiconductor industry. The characterization of individual devices is instrumental to engineers and integrated circ ...

is showing potential for conventional IC failure analysis and debugging, as well as for transistor design, circuit, and process development, and even for yield engineering.

References

External links

frost.com
Nanotechnology {{nano-tech-stub

See also

References

External links